Incidence of atrial fibrillation in conjunction with breast cancer.
Age
Atrial fibrillation
Breast cancer
Cohort study
Nationwide
Risk factors
Women
Journal
Heart rhythm
ISSN: 1556-3871
Titre abrégé: Heart Rhythm
Pays: United States
ID NLM: 101200317
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
02
08
2018
pubmed:
3
2
2019
medline:
22
9
2020
entrez:
3
2
2019
Statut:
ppublish
Résumé
Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments. The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population. We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Female patients with breast cancer were matched (1:3) by age and sex with the background population. The long-term incidence of AF was estimated by cumulative incidence curves and multivariable Cox regression models. We matched 74,155 patients with breast cancer with 222,465 patients from the background population. Breast cancer was associated with incident AF and the association differed between age groups (interaction analysis, P < .0001) and follow-up time periods. In patients younger than 60 years breast cancer was associated with increased incidence of AF during the first 6 months (hazard ratio [HR] 2.10; 95% confidence interval [CI] 1.25-3.44) and from 6 months to 3 years (HR 1.80; 95% CI 1.38-2.35). In patients older than 60 years, breast cancer was not associated with increased incidence of AF during the first 6 months (HR 1.13; 95% CI 0.95-1.34) and was associated with increased incidence of AF from 6 months to 3 years (HR 1.14; 95% CI 1.05-1.25). The long-term incidence of AF was increased in patients with breast cancer and short-term incidence was increased in patients younger than 60 years and similar in patients older than 60 years compared with the background population.
Sections du résumé
BACKGROUND
Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments.
OBJECTIVE
The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population.
METHODS
We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries. Female patients with breast cancer were matched (1:3) by age and sex with the background population. The long-term incidence of AF was estimated by cumulative incidence curves and multivariable Cox regression models.
RESULTS
We matched 74,155 patients with breast cancer with 222,465 patients from the background population. Breast cancer was associated with incident AF and the association differed between age groups (interaction analysis, P < .0001) and follow-up time periods. In patients younger than 60 years breast cancer was associated with increased incidence of AF during the first 6 months (hazard ratio [HR] 2.10; 95% confidence interval [CI] 1.25-3.44) and from 6 months to 3 years (HR 1.80; 95% CI 1.38-2.35). In patients older than 60 years, breast cancer was not associated with increased incidence of AF during the first 6 months (HR 1.13; 95% CI 0.95-1.34) and was associated with increased incidence of AF from 6 months to 3 years (HR 1.14; 95% CI 1.05-1.25).
CONCLUSION
The long-term incidence of AF was increased in patients with breast cancer and short-term incidence was increased in patients younger than 60 years and similar in patients older than 60 years compared with the background population.
Identifiants
pubmed: 30709772
pii: S1547-5271(18)31044-0
doi: 10.1016/j.hrthm.2018.10.017
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-348Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.