MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in


Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
04 2019
Historique:
received: 31 07 2018
revised: 05 12 2018
accepted: 29 01 2019
pubmed: 3 2 2019
medline: 30 5 2020
entrez: 3 2 2019
Statut: ppublish

Résumé

Although the majority of

Identifiants

pubmed: 30709805
pii: 2159-8290.CD-18-0879
doi: 10.1158/2159-8290.CD-18-0879
pmc: PMC10151004
mid: NIHMS1556978
doi:

Substances chimiques

Proto-Oncogene Proteins B-raf EC 2.7.11.1
MAP Kinase Kinase Kinases EC 2.7.11.25

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

526-545

Subventions

Organisme : NCI NIH HHS
ID : R01 CA111754
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2019 American Association for Cancer Research.

Références

Nature. 2012 Jan 18;481(7381):287-94
pubmed: 22258607
Bioinformatics. 2010 Oct 1;26(19):2438-44
pubmed: 20709693
J Clin Invest. 2014 Jan;124(1):30-9
pubmed: 24382387
Cancer Discov. 2014 May;4(5):516-8
pubmed: 24795010
N Engl J Med. 2015 Jan 1;372(1):30-9
pubmed: 25399551
J Clin Oncol. 2009 Dec 1;27(34):5743-50
pubmed: 19805672
Nat Rev Cancer. 2016 Feb;16(2):110-20
pubmed: 26775620
Int J Biochem Cell Biol. 2003 Aug;35(8):1210-26
pubmed: 12757758
Annu Rev Biochem. 2010;79:181-211
pubmed: 20192759
Nat Rev Mol Cell Biol. 2010 Mar;11(3):196-207
pubmed: 20177395
Nat Rev Drug Discov. 2014 Sep;13(9):673-91
pubmed: 25131830
Adv Cancer Res. 2012;116:87-129
pubmed: 23088869
Oncologist. 2016 Aug;21(8):940-5
pubmed: 27317574
Nat Struct Mol Biol. 2010 Sep;17(9):1144-51
pubmed: 20802485
Nat Chem Biol. 2016 Sep;12(9):748-54
pubmed: 27454931
Nature. 2005 Apr 14;434(7035):917-21
pubmed: 15829967
Pharm Res. 2015 Mar;32(3):779-92
pubmed: 24203492
Nat Rev Clin Oncol. 2017 Aug;14(8):463-482
pubmed: 28374786
Cancer Discov. 2014 Jul;4(7):816-27
pubmed: 24771846
N Engl J Med. 2005 Mar 10;352(10):997-1003
pubmed: 15758010
Bioinformatics. 2017 Aug 01;33(15):2413-2415
pubmed: 28379339
Lancet. 2015 Aug 1;386(9992):444-51
pubmed: 26037941
Clin Cancer Res. 2017 Jun 1;23(11):2691-2701
pubmed: 27979916
Oncol Rep. 2012 Aug;28(2):654-8
pubmed: 22614944
PLoS One. 2013 Jul 03;8(7):e67583
pubmed: 23844038
DNA Repair (Amst). 2015 Jun;30:53-67
pubmed: 25881042
Nat Commun. 2014;5:3361
pubmed: 24553445
Cell. 2015 Jun 18;161(7):1681-96
pubmed: 26091043
Cancer Discov. 2014 Jan;4(1):94-109
pubmed: 24265153
Mol Cancer Ther. 2013 Oct;12(10):2078-87
pubmed: 23939379
Nat Rev Cancer. 2012 Jan 12;12(2):104-20
pubmed: 22237395
Lancet Oncol. 2017 Apr;18(4):435-445
pubmed: 28284557
Nat Rev Genet. 2016 Sep 15;17(10):630-41
pubmed: 27629931
Cancer Res. 2011 Apr 1;71(7):2750-60
pubmed: 21317224
Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3041-6
pubmed: 18287029
Mol Cancer Ther. 2008 Apr;7(4):759-68
pubmed: 18413790
Int J Cancer. 2015 Jun 15;136(12):2844-53
pubmed: 25400033
Nature. 2013 Dec 5;504(7478):138-42
pubmed: 24185007
Clin Cancer Res. 2013 Dec 15;19(24):6882-90
pubmed: 24097867
J Biol Chem. 2009 Nov 13;284(46):31945-52
pubmed: 19783859
Cancer Discov. 2013 Mar;3(3):350-62
pubmed: 23288408
Pigment Cell Melanoma Res. 2008 Aug;21(4):457-63
pubmed: 18627530
JCO Precis Oncol. 2017 Jun 23;1:
pubmed: 32913971
Cancer Discov. 2013 Mar;3(3):338-49
pubmed: 23171796
Nucleic Acids Res. 2014 May;42(9):5616-32
pubmed: 24598253

Auteurs

Ophélia Maertens (O)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
Ludwig Center at Harvard, Boston, Massachusetts.

Ryan Kuzmickas (R)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Haley E Manchester (HE)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Chloe E Emerson (CE)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Alessandra G Gavin (AG)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Caroline J Guild (CJ)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Terence C Wong (TC)

Department of Medical Oncology, Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Thomas De Raedt (T)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Christian Bowman-Colin (C)

Harvard Medical School, Boston, Massachusetts.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Elodie Hatchi (E)

Harvard Medical School, Boston, Massachusetts.
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.

Levi A Garraway (LA)

Harvard Medical School, Boston, Massachusetts.
Ludwig Center at Harvard, Boston, Massachusetts.
Department of Medical Oncology, Center for Cancer Precision Medicine, Dana-Farber Cancer Institute, Boston, Massachusetts.
Cancer Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.

Keith T Flaherty (KT)

Harvard Medical School, Boston, Massachusetts.
Department of Medical Oncology, Massachusetts General Hospital, Boston, Massachusetts.

Shailja Pathania (S)

Center for Personalized Cancer Therapy, University of Massachusetts, Boston, Massachusetts.

Stephen J Elledge (SJ)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.
Ludwig Center at Harvard, Boston, Massachusetts.
Department of Genetics, Howard Hughes Medical Institute, Boston, Massachusetts.

Karen Cichowski (K)

Genetics Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. kcichowski@rics.bwh.harvard.edu.
Harvard Medical School, Boston, Massachusetts.
Ludwig Center at Harvard, Boston, Massachusetts.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH