Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine.

Adult Biomarkers / metabolism Case-Control Studies Chronic Disease Female Globus Pallidus / diagnostic imaging Humans Image Processing, Computer-Assisted Iron / metabolism Magnetic Resonance Imaging Male Migraine Disorders / diagnostic imaging Periaqueductal Gray / diagnostic imaging Prospective Studies Red Nucleus / diagnostic imaging Sensitivity and Specificity

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
05 03 2019
Historique:
received: 27 08 2018
accepted: 31 10 2018
pubmed: 3 2 2019
medline: 20 11 2019
entrez: 3 2 2019
Statut: ppublish

Résumé

To study iron deposition in red nucleus (RN), globus pallidus (GP), and periaqueductal gray matter (PAG) as a potential biomarker of chronic migraine (CM) and its association with levels of biomarkers related to migraine pathophysiology. This case-control study included 112 patients with migraine (55 CM, 57 episodic migraine [EM]) and 25 headache-free controls. We analyzed iron deposition using 3T MRI and the NIH software platform ImageJ; we analyzed serum levels of markers of inflammation, endothelial dysfunction, and blood-brain barrier (BBB) disruption by ELISA in peripheral blood during interictal periods. Patients with CM showed larger iron grounds volume in RN compared to patients with EM (70.2 ± 6.8 vs 25.5 ± 7.3 μL, Patients with CM showed increased iron deposition in RN and PAG compared to patients with EM and controls. Iron grounds volume in PAG identified correctly patients with CM and was associated with elevated biomarkers of endothelial dysfunction and BBB disruption.

Identifiants

DOI: 10.1212/WNL.0000000000007047 PMID: 30709968
pubmed: 30709968
pii: WNL.0000000000007047
doi: 10.1212/WNL.0000000000007047
doi:

Substances chimiques

Biomarkers 0
Iron E1UOL152H7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e1076-e1085

Commentaires et corrections

Type : ErratumIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© 2019 American Academy of Neurology.

Auteurs

Clara Domínguez (C)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Ana López (A)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Pedro Ramos-Cabrer (P)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Alba Vieites-Prado (A)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Maria Pérez-Mato (M)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Carmen Villalba (C)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Tomás Sobrino (T)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Xiana Rodriguez-Osorio (X)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Francisco Campos (F)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

José Castillo (J)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain.

Rogelio Leira (R)

From the Departments of Neurology (C.D., A.L., X.R.-O., R.L.) and Radiology (C.V.), Hospital Clinico Universitario, Universidade de Santiago de Compostela; Clinical Neurosciences Research Laboratory (A.V.-P., M.P.-M., T.S., F.C., J.C., R.L.), Health Research Institute of Santiago de Compostela; Magnetic Resonance Imaging (P.R.-C.), Molecular Imaging Unit, CIC biomaGUNE, Donostia-San Sebastian; and Ikerbasque (P.R.-C.), The Basque Foundation for Science, Bilbao, Spain. rogelio.leira.muino@sergas.es.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Globus pallidus › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Fer › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Substance grise centrale du mésencéphale › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Iron deposition in periaqueductal gray matter...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Noyau rouge › Iron deposition in periaqueductal gray matter...
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