PP2ACα deficiency impairs early cortical development through inducing DNA damage in neuroprojenitor cells.

Animals Brain / cytology Carrier Proteins / metabolism Cell Proliferation Cognition DNA Damage Gene Deletion Histones / metabolism Kruppel-Like Transcription Factors / metabolism Mice Microcephaly / enzymology Neocortex / metabolism Neural Stem Cells / cytology Protein Phosphatase 2C / deficiency Protein Serine-Threonine Kinases / metabolism Tumor Suppressor Protein p53 / metabolism
Brain development DNA damage Protein phosphorylation Signaling cascade Stem cell

Journal

The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482

Informations de publication

Date de publication:
04 2019
Historique:
received: 14 11 2018
revised: 25 01 2019
accepted: 29 01 2019
pubmed: 3 2 2019
medline: 4 12 2019
entrez: 3 2 2019
Statut: ppublish

Résumé

The role of protein phosphatase 2ACα (PP2ACα) in brain development is poorly understood. To understand the function of PP2ACα in neurogenesis, we inactivated Pp2acα gene in the central nervous system (CNS) of mice by Cre/LoxP system and generated the PP2ACα deficient mice (designated as the Pp2acα

Identifiants

DOI: 10.1016/j.biocel.2019.01.021 PMID: 30710753
pubmed: 30710753
pii: S1357-2725(19)30027-5
doi: 10.1016/j.biocel.2019.01.021
pii:
doi:

Substances chimiques

Carrier Proteins 0
H1f4 protein, mouse 0
Hic1 protein, mouse 0
Histones 0
Kruppel-Like Transcription Factors 0
Tumor Suppressor Protein p53 0
Hipk2 protein, mouse EC 2.7.1.-
Protein Serine-Threonine Kinases EC 2.7.11.1
Ppm1a protein, mouse EC 3.1.3.16
Protein Phosphatase 2C EC 3.1.3.16

Types de publication

Journal Article Retracted Publication

Langues

eng

Sous-ensembles de citation

IM

Pagination

40-58

Commentaires et corrections

Type : RetractionIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Bo Liu (B)

Department of Otorhinolaryngology Head&Neck Surgery, University of Maryland School of Medicine, Baltimore, USA; University of Macau, Macau, China. Electronic address: lbfhsum@yeah.net.

Lin Lin (L)

University of Macau, Macau, China; Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Sciences. Beijing, China.

Saima Riazuddin (S)

Department of Otorhinolaryngology Head&Neck Surgery, University of Maryland School of Medicine, Baltimore, USA.

Ahmed Zubair (A)

Department of Otorhinolaryngology Head&Neck Surgery, University of Maryland School of Medicine, Baltimore, USA.

Li Wang (L)

Branch of Cancer Research, Jones Hopkins University, Baltimore, USA.

Li-Jun Di (LJ)

Branch of Cancer Research, Jones Hopkins University, Baltimore, USA.

Rui Li (R)

Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Sciences. Beijing, China. Electronic address: boliufhs@umac.mo.

Ting-Ting Dong (TT)

Department of Pathology, Institute of Basic Medical Sciences, Chinese Academy of Sciences. Beijing, China; China Agricultural University, Beijing, China.

Chu-Xia Deng (CX)

National Institute of Neurological Disorders and Stroke, National Institute of Heath, Bethesda, USA. Electronic address: cxdeng@nih.gov.

Wei-Min Tong (WM)

National Institute of Neurological Disorders and Stroke, National Institute of Heath, Bethesda, USA. Electronic address: wmtong@nih.gov.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Malformations › Malformations du système nerveux › Malformations corticales › Malformations corticales du groupe I › Microcéphalie › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Néocortex › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoprotein Phosphatases › Protein phosphatase 2C › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › PP2ACα deficiency impairs early cortical...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › PP2ACα deficiency impairs early cortical...