Pathophysiology behind prolonged whiplash associated disorders: study protocol for an experimental study.
Biomarkers
/ metabolism
Brain
/ diagnostic imaging
Cervical Vertebrae
/ diagnostic imaging
Disability Evaluation
Exercise Therapy
Humans
Kinesthesis
Magnetic Resonance Imaging
Multicenter Studies as Topic
Neck Muscles
/ diagnostic imaging
Pain Measurement
Postural Balance
Prospective Studies
Recovery of Function
Research Design
Saliva
/ metabolism
Sweden
Treatment Outcome
Ultrasonography
Whiplash Injuries
/ blood
Biomarkers
Chronic
Diagnostic imaging
Exercise therapy
Follow-up study
MRI
Neck
Outcome
Physiopathology
Physiotherapy
Randomized
Rehabilitation
Scan
Spine
Ultrasonography
Whiplash injury
Journal
BMC musculoskeletal disorders
ISSN: 1471-2474
Titre abrégé: BMC Musculoskelet Disord
Pays: England
ID NLM: 100968565
Informations de publication
Date de publication:
02 Feb 2019
02 Feb 2019
Historique:
received:
06
12
2018
accepted:
28
01
2019
entrez:
4
2
2019
pubmed:
4
2
2019
medline:
31
7
2019
Statut:
epublish
Résumé
There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by rehabilitation. The aims of the projects are to investigate imaging and molecular biomarkers, cervical kinaesthesia, postural sway and the association with pain, disability and other outcomes in individuals with longstanding WAD, before and after a neck-specific exercise intervention. Another aim is to compare individuals with WAD with healthy controls. Participants are a sub-group (n = 30) of individuals recruited from an ongoing randomized controlled study (RCT). Measurements in this experimental prospective study will be carried out at baseline (before intervention) and at a three month follow-up (end of physiotherapy intervention), and will include muscle structure and inflammation using magnetic resonance imaging (MRI), brain structure and function related to pain using functional MRI (fMRI), muscle function using ultrasonography, biomarkers using samples of blood and saliva, cervical kinaesthesia using the "butterfly test" and static balance test using an iPhone app. Association with other measures (self-reported and clinical measures) obtained in the RCT (e.g. background data, pain, disability, satisfaction with care, work ability, quality of life) may be investigated. Healthy volunteers matched for age and gender will be recruited as controls (n = 30). The study results may contribute to the development of improved diagnostics and improved rehabilitation methods for WAD. Clinicaltrial.gov Protocol ID: NCT03664934, initial release 09/11/2018.
Sections du résumé
BACKGROUND
BACKGROUND
There is insufficient knowledge of pathophysiological parameters to understand the mechanism behind prolonged whiplash associated disorders (WAD), and it is not known whether or not changes can be restored by rehabilitation. The aims of the projects are to investigate imaging and molecular biomarkers, cervical kinaesthesia, postural sway and the association with pain, disability and other outcomes in individuals with longstanding WAD, before and after a neck-specific exercise intervention. Another aim is to compare individuals with WAD with healthy controls.
METHODS
METHODS
Participants are a sub-group (n = 30) of individuals recruited from an ongoing randomized controlled study (RCT). Measurements in this experimental prospective study will be carried out at baseline (before intervention) and at a three month follow-up (end of physiotherapy intervention), and will include muscle structure and inflammation using magnetic resonance imaging (MRI), brain structure and function related to pain using functional MRI (fMRI), muscle function using ultrasonography, biomarkers using samples of blood and saliva, cervical kinaesthesia using the "butterfly test" and static balance test using an iPhone app. Association with other measures (self-reported and clinical measures) obtained in the RCT (e.g. background data, pain, disability, satisfaction with care, work ability, quality of life) may be investigated. Healthy volunteers matched for age and gender will be recruited as controls (n = 30).
DISCUSSION
CONCLUSIONS
The study results may contribute to the development of improved diagnostics and improved rehabilitation methods for WAD.
TRIAL REGISTRATION
BACKGROUND
Clinicaltrial.gov Protocol ID: NCT03664934, initial release 09/11/2018.
Identifiants
pubmed: 30711003
doi: 10.1186/s12891-019-2433-3
pii: 10.1186/s12891-019-2433-3
pmc: PMC6359872
doi:
Substances chimiques
Biomarkers
0
Banques de données
ClinicalTrials.gov
['NCT03664934']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Pagination
51Subventions
Organisme : Vetenskapsrådet
ID : 2018-02476
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