Dystrophin is required for normal synaptic gain in the Drosophila olfactory circuit.

Animals Calcium / metabolism Drosophila Proteins / metabolism Drosophila melanogaster / metabolism Dystrophin / metabolism Female Interneurons / metabolism Male Odorants Olfactory Pathways / physiology Olfactory Perception / physiology Olfactory Receptor Neurons / physiology Smell / physiology Synapses / physiology
Antennal lobe Behavior Drosophila melanogaster Dystrophin Olfaction Olfactory receptor neurons Projection neurons

Journal

Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503

Informations de publication

Date de publication:
01 06 2019
Historique:
received: 12 09 2018
revised: 28 01 2019
accepted: 30 01 2019
pubmed: 4 2 2019
medline: 12 9 2020
entrez: 4 2 2019
Statut: ppublish

Résumé

The Drosophila olfactory system provides an excellent model to elucidate the neural circuits that control behaviors elicited by environmental stimuli. Despite significant progress in defining olfactory circuit components and their connectivity, little is known about the mechanisms that transfer the information from the primary antennal olfactory receptor neurons to the higher order brain centers. Here, we show that the Dystrophin Dp186 isoform is required in the olfactory system circuit for olfactory functions. Using two-photon calcium imaging, we found the reduction of calcium influx in olfactory receptor neurons (ORNs) and also the defect of GABA

Identifiants

DOI: 10.1016/j.brainres.2019.01.039 PMID: 30711401
pubmed: 30711401
pii: S0006-8993(19)30063-0
doi: 10.1016/j.brainres.2019.01.039
pii:
doi:

Substances chimiques

Drosophila Proteins 0
Dystrophin 0
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

158-166

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Salinee Jantrapirom (S)

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand.

De-Shou Cao (DS)

Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093, USA.

Jing W Wang (JW)

Division of Biological Sciences, University of California-San Diego, La Jolla, CA 92093, USA.

Huey Hing (H)

Department of Biology, State University of New York, Brockport, NY, USA.

Christopher J Tabone (CJ)

School of Life Sciences, University of Nevada, Las Vegas, NV, USA.

Kathryn Lantz (K)

School of Life Sciences, University of Nevada, Las Vegas, NV, USA.

J Steven de Belle (JS)

MnemOdyssey LLC, Escondido, CA, USA.

Yu Tong Qiu (YT)

Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands.

Hans M Smid (HM)

Laboratory of Entomology, Wageningen University, Wageningen, The Netherlands.

Masamitsu Yamaguchi (M)

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo, Kyoto 606-8585, Japan.

Lee G Fradkin (LG)

Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands; University of Massachusetts Medical School, MA, USA.

Jasprina N Noordermeer (JN)

Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

Saranyapin Potikanond (S)

Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Thailand; Laboratory of Developmental Neurobiology, Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: saranyapin.p@cmu.ac.th.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Dystrophine › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Environnement et santé publique › Environnement › Odorisants › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Système nerveux › Voies nerveuses › Voies afférentes › Voies olfactives › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception olfactive › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Cellules chimioréceptrices › Neurorécepteurs olfactifs › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Odorat › Dystrophin is required for normal synaptic...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Dystrophin is required for normal synaptic...