Multiple pharmacognostic characterization on hemp commercial cultivars: Focus on inflorescence water extract activity.
Animals
Anti-Bacterial Agents
/ isolation & purification
Anti-Inflammatory Agents
/ isolation & purification
Antifungal Agents
/ isolation & purification
Antioxidants
/ isolation & purification
Artemia
Candida albicans
/ drug effects
Cannabis
/ chemistry
Colon
/ drug effects
Escherichia coli
/ drug effects
HCT116 Cells
Humans
Inflorescence
/ chemistry
Male
Microbial Sensitivity Tests
Plant Extracts
/ isolation & purification
Pseudomonas aeruginosa
/ drug effects
Rats, Sprague-Dawley
Staphylococcus aureus
/ drug effects
Water
/ chemistry
Antimicrobial activity
Hemp
Inflammation
Oxidative stress
Ulcerative colitis
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
31
10
2018
revised:
25
01
2019
accepted:
28
01
2019
pubmed:
4
2
2019
medline:
21
5
2019
entrez:
4
2
2019
Statut:
ppublish
Résumé
One of the most promising economic perspectives of hemp production chain is female inflorescence valorization, despite there being actually no chemical composition or biological data from water fraction. In this context, the focus of this study is the evaluation of protective effects related to hemp water flower extracts from four commercial cultivars (Futura 75, Kc virtus, Carmagnola Cs and Villanova). We evaluated the phytochemical profile through validated spectrophotometric and HPLC methods. Then, we studied the biological activity on C2C12 and HCT116 cell lines, and in an ex vivo experimental model of ulcerative colitis, constituted by isolated LPS-stimulated colon. Particularly, we assayed the blunting effects induced by hemp water extract treatment on LPS-induced levels of nitrites, malondialdehyde (MDA), prostaglandin (PG)E
Identifiants
pubmed: 30711720
pii: S0278-6915(19)30046-8
doi: 10.1016/j.fct.2019.01.035
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anti-Inflammatory Agents
0
Antifungal Agents
0
Antioxidants
0
Plant Extracts
0
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
452-461Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.