Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Acetylcholinesterase / metabolism Alzheimer Disease / drug therapy Butyrylcholinesterase / metabolism Cholinesterase Inhibitors / chemical synthesis Chromones / chemistry Donepezil / chemistry Dose-Response Relationship, Drug Humans Melatonin / chemistry Molecular Docking Simulation Molecular Structure Monoamine Oxidase / metabolism Monoamine Oxidase Inhibitors / chemical synthesis Structure-Activity Relationship
Antioxidant MAO-A MAO-B ORAC Ugi-4MCR cholinesterases donepezil

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2019
Historique:
entrez: 5 2 2019
pubmed: 5 2 2019
medline: 23 2 2019
Statut: ppublish

Résumé

We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC

Identifiants

DOI: 10.1080/14756366.2018.1545766 PMID: 30712420 PMC: PMC6366423
pubmed: 30712420
doi: 10.1080/14756366.2018.1545766
pmc: PMC6366423
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Chromones 0
Monoamine Oxidase Inhibitors 0
Donepezil 8SSC91326P
Monoamine Oxidase EC 1.4.3.4
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8
Melatonin JL5DK93RCL

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

479-489

Références

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Auteurs

Irene Pachón-Angona (I)

a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.

Bernard Refouvelet (B)

a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.

Rudolf Andrýs (R)

b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.

Helène Martin (H)

c PEPITE EA4267, Laboratoire de Toxicologie Cellulaire , University Bourgogne Franche-Comté , Besançon , France.

Vincent Luzet (V)

a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.

Isabel Iriepa (I)

d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.
e Institute of Chemical Research Andrés M. del Río , Alcalà University , Madrid , Spain.

Ignacio Moraleda (I)

d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.

Daniel Diez-Iriepa (D)

d Department of Organic Chemistry and Inorganic Chemistry , Alcalà University , Madrid , Spain.
e Institute of Chemical Research Andrés M. del Río , Alcalà University , Madrid , Spain.

María-Jesús Oset-Gasque (MJ)

f Instituto de Investigación en Neuroquímica , Universidad Complutense de Madrid , Madrid , Spain.
g Department of Biochemistry and Molecular Biology, School of Pharmacy , Plaza de Ramòn y Cajal , Madrid , Spain.

José Marco-Contelles (J)

h Laboratory of Medicinal Chemistry (IQOG, CSIC) , Madrid , Spain.

Kamil Musilek (K)

b Faculty of Science, Department of Chemistry , University of Hradec Kralove , Hradec Kralove , Czech Republic.
ORCID: 0000-0002-7504-4062

Lhassane Ismaili (L)

a Neurosciences intégratives et cliniques, Pôle Chimie Organique et Thérapeutique , University Bourgogne Franche-Comté , Besançon , France.
ORCID: 0000-0002-6013-3150

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Indènes › Indanes › Donépézil › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Mélatonine › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-NH2 group donors › Monoamine oxidase › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de la monoamine oxydase › Donepezil + chromone + melatonin hybrids as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Donepezil + chromone + melatonin hybrids as...