American Trypanosomiasis (Chagas Disease).

Animals Chagas Cardiomyopathy / drug therapy Chagas Disease / complications Clinical Trials as Topic Disease Progression Disease Vectors Humans Nitroimidazoles / therapeutic use Triatominae / parasitology Trypanocidal Agents / therapeutic use Trypanosoma cruzi / isolation & purification
Cardiomyopathy Chagas disease Heart failure Parasitology Trypanosomiasis

Journal

Infectious disease clinics of North America
ISSN: 1557-9824
Titre abrégé: Infect Dis Clin North Am
Pays: United States
ID NLM: 8804508

Informations de publication

Date de publication:
03 2019
Historique:
entrez: 5 2 2019
pubmed: 5 2 2019
medline: 8 11 2019
Statut: ppublish

Résumé

American trypanosomiasis is caused by a parasite endemic of the Americas. Current migration has globalized Chagas disease. Acute infection usually resolves spontaneously. Nonetheless, 20% to 40% develop cardiomyopathy 20 to 30 years later. Progression to cardiomyopathy is devastatingly rapid, manifesting with heart failure and sudden death. Etiologic treatment is highly effective and recommended in those with acute infections, congenital infections, and parasite reactivation, and women of childbearing age, but in asymptomatic Trypanosoma cruzi carriers and patients with early cardiomyopathy remains controversial and under investigation. Progression of heart failure is rapid and accounts for most of the morbidity and related mortality.

Identifiants

DOI: 10.1016/j.idc.2018.10.015 PMID: 30712757
pubmed: 30712757
pii: S0891-5520(18)30104-1
doi: 10.1016/j.idc.2018.10.015
pii:
doi:

Substances chimiques

Nitroimidazoles 0
Trypanocidal Agents 0
benzonidazole YC42NRJ1ZD

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

119-134

Subventions

Organisme : CIHR
Pays : Canada

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Luis E Echeverria (LE)

Grupo de Estudios Epidemiológicos y Salud Pública, Heart Failure and Heart Transplant Clinic, Fundacion Cardiovascular de Colombia, Calle 155 A No. 23-58, Urbanizacion El Bosque, Floridablanca, Santander, Colombia.

Carlos A Morillo (CA)

Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Foothills Medical Centre, Room C823, 1403 29th Street Northwest, Calgary, Alberta T2N 2T9, Canada. Electronic address: carlos.morillo@ucalgary.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Cardiomyopathie associée à la maladie de Chagas › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Chaîne d'infection › Vecteurs de maladies › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Nitroimidazoles › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Hemiptera › Heteroptera › Reduviidae › Triatominae › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › American Trypanosomiasis (Chagas Disease).
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › American Trypanosomiasis (Chagas Disease).