[An unusual case of olmesartan induced enteropathy].
Un cas inhabituel d’entéropathie secondaire à la prise d’olmesartan.
Antihypertensive Agents
/ adverse effects
Chronic Disease
Dehydration
/ chemically induced
Diarrhea
/ chemically induced
Gastrointestinal Diseases
/ chemically induced
Humans
Imidazoles
/ adverse effects
Intestinal Mucosa
/ drug effects
Male
Middle Aged
Rare Diseases
/ chemically induced
Tetrazoles
/ adverse effects
Weight Loss
Atrophie villositaire
Enteropathy
Entéropathie
Hyperlymphocytose intraépithéliale pandigestive
Olmesartan
Panlymphocytosis
Villous atrophy
Journal
Annales de pathologie
ISSN: 0242-6498
Titre abrégé: Ann Pathol
Pays: France
ID NLM: 8106337
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
18
05
2018
revised:
18
10
2018
accepted:
29
10
2018
pubmed:
5
2
2019
medline:
7
1
2020
entrez:
5
2
2019
Statut:
ppublish
Résumé
Olmesartan induced enteropathy was first described in 2012. It is a rare adverse effect of this antihypertensive drug. The clinical presentation commonly includes severe chronic diarrhea leading to weight loss and a variable degree of dehydration. Histological findings are most commonly observed in the duodenum and consist of partial or total villous atrophy, increased intraepithelial lymphocytes and inflammation in the lamina propria. Involvement of gastric and colic mucosa has also been described. We report on the case of a 63-year-old man, treated by olmesartan, who presented with severe chronic diarrhea. Biopsies from different levels of the gastrointestinal tract revealed a pandigestive intraepithelial lymphocytosis.
Identifiants
pubmed: 30712983
pii: S0242-6498(18)30183-4
doi: 10.1016/j.annpat.2018.10.007
pii:
doi:
Substances chimiques
Antihypertensive Agents
0
Imidazoles
0
Tetrazoles
0
olmesartan
8W1IQP3U10
Types de publication
Case Reports
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
237-240Informations de copyright
Copyright © 2018 Elsevier Masson SAS. All rights reserved.