Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination.


Journal

Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581

Informations de publication

Date de publication:
06 03 2019
Historique:
received: 20 09 2018
revised: 08 01 2019
accepted: 11 01 2019
pmc-release: 06 03 2020
pubmed: 5 2 2019
medline: 18 12 2019
entrez: 5 2 2019
Statut: ppublish

Résumé

Hepatitis B virus (HBV) core (HBV-C) antigens with homologous or heterologous HIV-tat48-57-like (HBV-C149tat) cationic domains non-specifically bind cellular RNA in vector-transfected cells. Here, we investigated whether RNA-binding to cationic domains influences the immunogenicity of endogenously expressed antigens delivered by DNA vaccination. We initially evaluated induction of HBV-C (K

Identifiants

pubmed: 30713086
pii: S1525-0016(19)30014-0
doi: 10.1016/j.ymthe.2019.01.011
pmc: PMC6403493
pii:
doi:

Substances chimiques

Toll-Like Receptor 7 0
Vaccines, DNA 0
RNA 63231-63-0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

661-672

Informations de copyright

Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

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Auteurs

Jana Krieger (J)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Petra Riedl (P)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Katja Stifter (K)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Gleyder Roman-Sosa (G)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Thomas Seufferlein (T)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Martin Wagner (M)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany.

Reinhold Schirmbeck (R)

Department of Internal Medicine I, Ulm University Hospital, Albert Einstein Allee 23, 89081 Ulm, Germany. Electronic address: reinhold.schirmbeck@uni-ulm.de.

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Classifications MeSH