Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis.
arthritis
chemokines
inflammation
Journal
RMD open
ISSN: 2056-5933
Titre abrégé: RMD Open
Pays: England
ID NLM: 101662038
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
04
2018
revised:
21
11
2018
accepted:
25
11
2018
entrez:
5
2
2019
pubmed:
5
2
2019
medline:
5
2
2019
Statut:
epublish
Résumé
We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2) to be a key regulator of proinflammatory cytokines in macrophages. In the study presented here, we investigated the role of MKP-2 in inflammatory arthritis with a particular focus on neutrophils. To achieve this, we subjected MKP-2 deficient and wild type mice to collagen antibody induced arthritis, an innate model of arthritis, and determined disease pathology. To further our investigation, we depleted neutrophils in a prophylactic and therapeutic fashion. Last, we used chemotaxis assays to analyse the impact of MKP-2 deletion on neutrophil migration. MKP-2 This is the first study to show a protective role for MKP-2 in inflammatory arthritis.
Identifiants
pubmed: 30713718
doi: 10.1136/rmdopen-2018-000711
pii: rmdopen-2018-000711
pmc: PMC6340532
doi:
Substances chimiques
Cytokines
0
Inflammation Mediators
0
MKP2 protein, mouse
EC 3.1.3.48
Protein Tyrosine Phosphatases
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
e000711Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT089273MA
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Immunol. 2006 Feb 1;176(3):1899-907
pubmed: 16424221
Cancer Metastasis Rev. 2008 Jun;27(2):253-61
pubmed: 18330678
Rheum Dis Clin North Am. 2010 May;36(2):367-83
pubmed: 20510239
FEBS J. 2013 Jan;280(2):489-504
pubmed: 22812510
Arthritis Rheum. 2000 Nov;43(11):2501-12
pubmed: 11083274
PLoS Pathog. 2013 Aug;9(8):e1003535
pubmed: 23966857
Nat Med. 2009 Apr;15(4):417-24
pubmed: 19330010
Cell Signal. 2006 Apr;18(4):479-87
pubmed: 15970427
Oncogene. 2009 Aug 6;28(31):2773-83
pubmed: 19525976
Infect Immun. 2010 Jun;78(6):2868-76
pubmed: 20351138
J Exp Med. 2014 Jun 30;211(7):1307-14
pubmed: 24913232
Immunology. 2006 Oct;119(2):195-202
pubmed: 16836650
Autoimmun Rev. 2005 Mar;4(3):130-6
pubmed: 15823498
Eur J Immunol. 2012 Feb;42(2):476-88
pubmed: 22101742
Circ Res. 2013 Jan 4;112(1):48-56
pubmed: 22993413
Nat Immunol. 2006 Mar;7(3):274-83
pubmed: 16474395
Nat Immunol. 2012 Mar 25;13(5):457-64
pubmed: 22447027
PLoS Pathog. 2010 Nov 11;6(11):e1001192
pubmed: 21085614
Infect Immun. 2008 Feb;76(2):532-41
pubmed: 18056477
Nature. 1980 Feb 14;283(5748):666-8
pubmed: 6153460
Oncogene. 2008 Sep 25;27(43):5684-95
pubmed: 18542059
PLoS Negl Trop Dis. 2013;7(2):e2064
pubmed: 23437409
Med Microbiol Immunol. 2013 Feb;202(1):25-35
pubmed: 22661217
Nat Med. 2009 Apr;15(4):455-61
pubmed: 19305414
BMC Musculoskelet Disord. 2010 Jun 29;11:136
pubmed: 20587038
Cell Death Dis. 2017 Apr 6;8(4):e2727
pubmed: 28383556
J Biol Chem. 2011 Apr 15;286(15):12933-43
pubmed: 21317287
Immunol Invest. 2013;42(7):555-622
pubmed: 24004059
J Biol Chem. 1995 Mar 31;270(13):7197-203
pubmed: 7535768
Nat Rev Immunol. 2011 Jul 25;11(8):519-31
pubmed: 21785456
J Interferon Cytokine Res. 2009 Jun;29(6):313-26
pubmed: 19441883
EMBO Rep. 2008 Oct;9(10):990-7
pubmed: 18704116
Nat Med. 2012 Jul;18(7):1052-9
pubmed: 22683778
Semin Immunol. 2017 Oct;33:52-57
pubmed: 29042029
Mol Biol Cell. 2013 Feb;24(3):373-84
pubmed: 23223570
Biochem Soc Trans. 2012 Feb;40(1):235-9
pubmed: 22260697
Cancer Res. 2010 Feb 15;70(4):1689-99
pubmed: 20124482
PLoS One. 2017 Aug 14;12(8):e0182923
pubmed: 28806729