Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer's disease.

Aged Alleles Alzheimer Disease / genetics Amyloid beta-Peptides / genetics Apolipoprotein E4 / genetics Cognition Cognitive Dysfunction / genetics Female Genetic Association Studies Genotype Glucuronidase / genetics Humans Klotho Proteins Male Middle Aged
Alzheimer's disease Cognition Episodic memory KL-VS Klotho Preclinical amyloid-β

Journal

Neurobiology of aging
ISSN: 1558-1497
Titre abrégé: Neurobiol Aging
Pays: United States
ID NLM: 8100437

Informations de publication

Date de publication:
04 2019
Historique:
received: 25 07 2018
revised: 04 12 2018
accepted: 27 12 2018
pubmed: 5 2 2019
medline: 18 12 2019
entrez: 5 2 2019
Statut: ppublish

Résumé

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer's disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) burden, and carriage of the apolipoprotein E (APOE) ε4 allele on cognitive decline. This study involved 581 Aβ-imaged, cognitively normal older adults, enrolled in the Australian Imaging, Biomarkers and Lifestyle Study of Aging. Linear mixed effects models revealed no significant associations between KL-VS and cognitive decline independently or in combination with Aβ burden and APOE ε4 genotype. Overall, previous associations reported between KL-VS and cognitive decline are not observed at the preclinical stages of AD. Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.

Identifiants

DOI: 10.1016/j.neurobiolaging.2018.12.014 PMID: 30716541
pubmed: 30716541
pii: S0197-4580(18)30454-8
doi: 10.1016/j.neurobiolaging.2018.12.014
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Apolipoprotein E4 0
Glucuronidase EC 3.2.1.31
Klotho Proteins EC 3.2.1.31

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

162-165

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Tenielle Porter (T)

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia.

Samantha C Burnham (SC)

CSIRO Health and Biosecurity, Parkville, Victoria, Australia; Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Lidija Milicic (L)

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia.

Greg Savage (G)

Department of Psychology, ARC Centre of Excellence in Cognition and its Disorders, Macquarie University, North Ryde, NSW, Australia.

Paul Maruff (P)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; CogState Ltd., Melbourne, Victoria, Australia.

Yen Ying Lim (YY)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.

David Ames (D)

Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia; National Ageing Research Institute, Parkville, Victoria, Australia.

Colin L Masters (CL)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.

Ralph N Martins (RN)

Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Stephanie Rainey-Smith (S)

Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.

Christopher C Rowe (CC)

Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia; Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.

Olivier Salvado (O)

CSIRO Health and Biosecurity/Australian e-Health Research Centre, Herston, Queensland, Australia.

David Groth (D)

School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Giuseppe Verdile (G)

Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia.

Victor L Villemagne (VL)

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia; Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia.

Simon M Laws (SM)

Collaborative Genomics Group, Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia. Electronic address: s.laws@ecu.edu.au.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucuronidase › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteur facteur croissance fibroblaste › Protéines Klotho › Klotho allele status is not associated with Aβ...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Klotho allele status is not associated with Aβ...