Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Feb 2019
Historique:
received: 04 01 2019
revised: 23 01 2019
accepted: 29 01 2019
entrez: 6 2 2019
pubmed: 6 2 2019
medline: 22 5 2019
Statut: epublish

Résumé

CX3CL1, which is a chemokine involved in many aspects of human pregnancy, is a membrane-bound chemokine shed into circulation as a soluble isoform. Placental CX3CL1 is induced by inflammatory cytokines and is upregulated in severe early-onset preeclampsia. In this study, the hypothesis was addressed whether angiotensin II can deregulate placental CX3CL1 expression, and whether CX3CL1 can promote a pro-inflammatory status of monocytes. qPCR analysis of human placenta samples (

Identifiants

pubmed: 30717334
pii: ijms20030641
doi: 10.3390/ijms20030641
pmc: PMC6387455
pii:
doi:

Substances chimiques

CX3CL1 protein, human 0
Chemokine CX3CL1 0
Cytokines 0
RNA, Messenger 0
Angiotensin II 11128-99-7

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Austrian Science Fund FWF
ID : DOC 31
Pays : Austria

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Auteurs

Olivia Nonn (O)

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Ageing, Medical University of Graz, 8010 Graz, Austria. olivia.nonn@medunigraz.at.

Jacqueline Güttler (J)

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Ageing, Medical University of Graz, 8010 Graz, Austria. jacqueline.serbin@medunigraz.at.

Désirée Forstner (D)

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Ageing, Medical University of Graz, 8010 Graz, Austria. desiree.forstner@medunigraz.at.

Sabine Maninger (S)

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Ageing, Medical University of Graz, 8010 Graz, Austria. sabine.maninger@medunigraz.at.

Julianna Zadora (J)

Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany. Julia.Zadora@mdc-berlin.de.
Max-Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany. Julia.Zadora@mdc-berlin.de.

András Balogh (A)

Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany. andras.balogh@mdc-berlin.de.
Berlin Institute of Health (BIH), 13125 Berlin, Germany. andras.balogh@mdc-berlin.de.

Alina Frolova (A)

Institute of Molecular Biology and Genetic of National Academy of Sciences of Ukraine, 03680 Kyiv, Ukraine. fshodan@gmail.com.

Andreas Glasner (A)

Femina Med Center, 8010 Graz, Austria. office@dr-glasner.at.

Florian Herse (F)

Experimental and Clinical Research Center, A Joint Cooperation Between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany. florian.herse@charite.de.
Max-Delbrueck Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany. florian.herse@charite.de.
Berlin Institute of Health (BIH), 13125 Berlin, Germany. florian.herse@charite.de.

Martin Gauster (M)

Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Ageing, Medical University of Graz, 8010 Graz, Austria. martin.gauster@medunigraz.at.

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Classifications MeSH