Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness.
amputees
fMRI
human
neuroplasticity
neuroscience
sensory deprivation
somatosensory cortex
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
05 02 2019
05 02 2019
Historique:
received:
10
04
2018
accepted:
12
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
27
3
2020
Statut:
epublish
Résumé
A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on persistent hand representation by studying individuals with acquired and congenital hand loss. We used representational similarity analysis in primary somatosensory and motor cortex during missing and intact hand movements. We found that key aspects of acquired amputees' missing hand representation persisted, despite varying vividness of phantom sensations. In contrast, missing hand representation of congenital one-handers, who do not experience phantom sensations, was significantly reduced. Across acquired amputees, individuals' reported motor control over their phantom hand positively correlated with the extent to which their somatosensory hand representation was normally organised. We conclude that once cortical organisation is formed, it is remarkably persistent, despite long-term attenuation of peripheral signals.
Identifiants
pubmed: 30717824
doi: 10.7554/eLife.37227
pii: 37227
pmc: PMC6363469
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome
ID : 104128/Z/14/Z
Pays : International
Organisme : Royal Society
ID : 104128/Z/14/Z
Pays : International
Informations de copyright
© 2019, Wesselink et al.
Déclaration de conflit d'intérêts
DW, Fv, NE, HD, LC, AT No competing interests declared, JD, TM Member of eLife BRE
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