NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 03 2019
15 03 2019
Historique:
received:
29
11
2017
accepted:
14
01
2019
pubmed:
6
2
2019
medline:
11
1
2020
entrez:
6
2
2019
Statut:
ppublish
Résumé
Tyrosine kinase 2 (TYK2) is a widely expressed receptor-associated kinase that is involved in signaling by a variety of cytokines with important immune regulatory activities. Absence of TYK2 in mice results in impaired NK cell maturation and antitumor activity, although underlying mechanisms are largely unknown. Using conditional ablation of TYK2 in NK cells we show that TYK2 is required for IFN-γ production by NK cells in response to IL-12 and for an efficient immune defense against
Identifiants
pubmed: 30718299
pii: jimmunol.1701649
doi: 10.4049/jimmunol.1701649
pmc: PMC6398083
doi:
Substances chimiques
TYK2 Kinase
EC 2.7.10.2
Tyk2 protein, mouse
EC 2.7.10.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1724-1734Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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