Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 Adult Research Participants Identify Loci in the
Calcium Channels, T-Type
/ genetics
Cell Adhesion Molecules
/ genetics
Drug Users
/ statistics & numerical data
Female
Genome-Wide Association Study
Humans
Impulsive Behavior
/ physiology
Male
Middle Aged
Peptides
Personality
/ genetics
Personality Tests
Polymorphism, Single Nucleotide
White People
/ genetics
BIS
GWAS
RDoC
UPPS-P
impulsivity
substance use disorders
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
27 03 2019
27 03 2019
Historique:
received:
05
10
2018
revised:
14
12
2018
accepted:
10
01
2019
pubmed:
6
2
2019
medline:
19
3
2020
entrez:
6
2
2019
Statut:
ppublish
Résumé
Impulsive personality traits are complex heritable traits that are governed by frontal-subcortical circuits and are associated with numerous neuropsychiatric disorders, particularly drug abuse and attention-deficit/hyperactivity disorder (ADHD). In collaboration with the genetics company 23andMe, we performed 10 genome-wide association studies on measures of impulsive personality traits [the short version of the UPPS-P Impulsive Behavior Scale, and the Barratt Impulsiveness Scale (BIS-11)] and drug experimentation (the number of drug classes an individual had tried in their lifetime) in up to 22,861 male and female adult human research participants of European ancestry. Impulsive personality traits and drug experimentation showed single nucleotide polymorphism heritabilities that ranged from 5 to 11%. Genetic variants in the
Identifiants
pubmed: 30718321
pii: JNEUROSCI.2662-18.2019
doi: 10.1523/JNEUROSCI.2662-18.2019
pmc: PMC6435820
doi:
Substances chimiques
CACNA1I protein, human
0
CADM2 protein, human
0
Calcium Channels, T-Type
0
Cell Adhesion Molecules
0
Peptides
0
lixisenatide
74O62BB01U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2562-2572Subventions
Organisme : NIDA NIH HHS
ID : P50 DA037844
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA002812
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH081482
Pays : United States
Informations de copyright
Copyright © 2019 the authors 0270-6474/19/392563-11$15.00/0.
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