miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling.
Adaptor Proteins, Signal Transducing
/ genetics
CD3 Complex
/ genetics
Class I Phosphatidylinositol 3-Kinases
/ genetics
HEK293 Cells
Humans
Jurkat Cells
MicroRNAs
/ genetics
NF-KappaB Inhibitor alpha
/ genetics
NF-kappa B
/ genetics
Phospholipase C gamma
/ genetics
Signal Transduction
/ immunology
T-Lymphocytes
/ immunology
Transfection
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
18 01 2019
18 01 2019
Historique:
received:
22
10
2018
accepted:
18
12
2018
revised:
13
12
2018
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
31
3
2020
Statut:
epublish
Résumé
NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4
Identifiants
pubmed: 30718475
doi: 10.1038/s41419-018-1295-1
pii: 10.1038/s41419-018-1295-1
pmc: PMC6362007
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
CD3 Complex
0
CD3E protein, human
0
MIRN34 microRNA, human
0
MicroRNAs
0
NF-kappa B
0
NFKBIA protein, human
0
TAB2 protein, human
0
NF-KappaB Inhibitor alpha
139874-52-5
Class I Phosphatidylinositol 3-Kinases
EC 2.7.1.137
PIK3CB protein, human
EC 2.7.1.137
PLCG1 protein, human
EC 3.1.4.11
Phospholipase C gamma
EC 3.1.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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