Catheter-related bloodstream infections with coagulase-negative staphylococci: are antibiotics necessary if the catheter is removed?
Aged
Anti-Bacterial Agents
/ therapeutic use
Bacteremia
/ drug therapy
Bacterial Proteins
/ genetics
Catheter-Related Infections
/ drug therapy
Coagulase
/ genetics
Device Removal
Female
Humans
Male
Middle Aged
Retrospective Studies
Staphylococcal Infections
/ drug therapy
Staphylococcus
/ enzymology
CRBSI
Central venous catheter
Coagulase-negative staphylococci
Intravascular catheter
Journal
Antimicrobial resistance and infection control
ISSN: 2047-2994
Titre abrégé: Antimicrob Resist Infect Control
Pays: England
ID NLM: 101585411
Informations de publication
Date de publication:
2019
2019
Historique:
received:
24
08
2018
accepted:
21
01
2019
entrez:
6
2
2019
pubmed:
6
2
2019
medline:
3
3
2020
Statut:
epublish
Résumé
Catheter-related bloodstream infections (CRBSI) with coagulase-negative Staphylococci (CoNS) are a common source of hospital-acquired bloodstream infections. The main objective of this study was to elucidate the role of systemic antibiotic therapy in the setting of catheter removal in adult patients with CoNS-CRBSI. We conducted a retrospective cohort study on patients with CoNS-CRBSI diagnosed between 2008 and 2016 with follow-up for up to 12 months. The main inclusion criterion was a removed intravascular catheter with quantitative catheter tip culture growing CoNS and the same CoNS identified in the blood culture of a given patient. Outcomes were Our study population comprised 184 CoNS-CRBSI episodes. Seventy-six percent received antibiotic treatment ≥5 days, while 17% did not receive therapy. Our findings indicate that withholding antimicrobial therapy in CoNS-CRBSI is neither associated with short-term complications nor with long-term recurrences.
Sections du résumé
Background
Catheter-related bloodstream infections (CRBSI) with coagulase-negative Staphylococci (CoNS) are a common source of hospital-acquired bloodstream infections. The main objective of this study was to elucidate the role of systemic antibiotic therapy in the setting of catheter removal in adult patients with CoNS-CRBSI.
Methods
We conducted a retrospective cohort study on patients with CoNS-CRBSI diagnosed between 2008 and 2016 with follow-up for up to 12 months. The main inclusion criterion was a removed intravascular catheter with quantitative catheter tip culture growing CoNS and the same CoNS identified in the blood culture of a given patient. Outcomes were
Results
Our study population comprised 184 CoNS-CRBSI episodes. Seventy-six percent received antibiotic treatment ≥5 days, while 17% did not receive therapy.
Conclusions
Our findings indicate that withholding antimicrobial therapy in CoNS-CRBSI is neither associated with short-term complications nor with long-term recurrences.
Identifiants
pubmed: 30719282
doi: 10.1186/s13756-019-0474-x
pii: 474
pmc: PMC6352346
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Coagulase
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
21Déclaration de conflit d'intérêts
The study was approved by the regional (Canton of Bern) ethics committee (project number 2017–01827).Not applicable (no individual person’s data).The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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