Impact of drugs on venous thromboembolism risk in surgical patients.
Analgesics
/ therapeutic use
Antidepressive Agents
/ therapeutic use
Antipsychotic Agents
/ therapeutic use
Contraceptives, Oral, Hormonal
/ therapeutic use
Diuretics
/ therapeutic use
Hormone Replacement Therapy
Humans
Hypnotics and Sedatives
/ therapeutic use
Perioperative Care
Risk Factors
Venous Thromboembolism
/ chemically induced
Analgesics
Antidepressants
Antipsychotics
Bridging anticoagulation
Diuretics
Oral contraceptives
Surgery
Thromboprophylaxis
Transfusion
Venous thromboembolism
Journal
European journal of clinical pharmacology
ISSN: 1432-1041
Titre abrégé: Eur J Clin Pharmacol
Pays: Germany
ID NLM: 1256165
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
15
10
2018
accepted:
21
01
2019
pubmed:
6
2
2019
medline:
26
11
2019
entrez:
6
2
2019
Statut:
ppublish
Résumé
This review focuses on the most common drugs administered to surgical patients during the perioperative period that affect the risk of venous thromboembolism (VTE). Among analgesics, the risk of VTE is increased in patients treated with diclofenac, ibuprofen, and rofecoxib, but not naproxen, while metamizole can confer a protective effect. The relationship between sedatives and VTE has not been sufficiently studied. Tricyclic antidepressants, low-potency serotonin reuptake inhibitors, and antipsychotics have been associated with increased risk of VTE. The use of diuretics in the perioperative period is poorly researched; however, hyponatremia is considered a risk factor. Other factors that may influence the risk of VTE include bridging anticoagulation, allogeneic transfusion, and hemostatic management before surgery. Pharmacotherapy for HIV or cancer may also increase VTE risk. Increased monitoring for VTE is therefore advisable in surgical patients and those receiving antipsychotics, antidepressants, diuretics, or analgesics.
Identifiants
pubmed: 30719565
doi: 10.1007/s00228-019-02636-x
pii: 10.1007/s00228-019-02636-x
doi:
Substances chimiques
Analgesics
0
Antidepressive Agents
0
Antipsychotic Agents
0
Contraceptives, Oral, Hormonal
0
Diuretics
0
Hypnotics and Sedatives
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
751-767Subventions
Organisme : Ministerstvo Zdravotnictv? Cesk? Republiky
ID : 17-29701A
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