Animals
Bronchoalveolar Lavage Fluid
Cytokines
/ metabolism
Epigenesis, Genetic
Inflammation
/ genetics
Lung Injury
/ genetics
Lysophospholipids
/ metabolism
Mice
Mice, Inbred C57BL
Pseudomonas Infections
/ genetics
Pseudomonas aeruginosa
/ pathogenicity
Signal Transduction
Sphingosine
/ analogs & derivatives
airway epithelium
bacterial infection
cystic fibrosis
pneumonia
respiratory infection
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
20
07
2018
revised:
06
12
2018
accepted:
02
01
2019
pubmed:
7
2
2019
medline:
12
11
2019
entrez:
7
2
2019
Statut:
ppublish
Résumé
Dysregulated sphingolipid metabolism has been implicated in the pathogenesis of various pulmonary disorders. Nuclear sphingosine-1-phosphate (S1P) has been shown to regulate histone acetylation, and therefore could mediate pro-inflammatory genes expression. Profile of sphingolipid species in bronchoalveolar lavage fluids and lung tissue of mice challenged with Genetic deletion of Our studies define a critical role for nuclear SPHK2/S1P signalling in epigenetic regulation of bacterial-mediated inflammatory lung injury. Targeting SPHK2 may represent a potential strategy to reduce lung inflammatory pulmonary disorders such as pneumonia and CF.
Identifiants
pubmed: 30723184
pii: thoraxjnl-2018-212378
doi: 10.1136/thoraxjnl-2018-212378
pmc: PMC6834354
mid: NIHMS1055378
doi:
Substances chimiques
Cytokines
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-591Subventions
Organisme : NCI NIH HHS
ID : R01 CA211095
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105947
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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