Role of Platelet Size Revisited-Function and Protein Composition of Large and Small Platelets.
Adolescent
Adult
Aged
Blood Platelets
/ metabolism
Blood Proteins
/ metabolism
Cell Size
Centrifugation
/ methods
Female
Humans
Integrin alpha2
/ blood
Integrin beta3
/ blood
Male
Mean Platelet Volume
Middle Aged
Platelet Adhesiveness
Platelet Membrane Glycoproteins
/ metabolism
Proteomics
/ methods
Receptors, Purinergic P2Y12
/ blood
Young Adult
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
pubmed:
7
2
2019
medline:
10
7
2019
entrez:
7
2
2019
Statut:
ppublish
Résumé
Epidemiological studies found an association between increased platelet size and the risk for thrombotic complications, but functional differences of large and small platelets remain poorly understood due to a lack of standardized protocols separating platelets with different size. We designed a protocol to separate large and small platelets from 15 mL whole blood. Separated large and small platelet fractions differed in mean platelet volume: 12.1 fl (10.3-13.8 fl) versus 7.7 fl (6.8-9.5 fl,
Identifiants
pubmed: 30727004
doi: 10.1055/s-0039-1677875
doi:
Substances chimiques
Blood Proteins
0
ITGB3 protein, human
0
Integrin alpha2
0
Integrin beta3
0
P2RY12 protein, human
0
Platelet Membrane Glycoproteins
0
Receptors, Purinergic P2Y12
0
platelet membrane glycoprotein VI
0
Types de publication
Comparative Study
Journal Article
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-420Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
None of the authors has a conflict of interest to declare with regard to this manuscript. T.T. declares a conflict outside of the submitted work: personal fees from Bristol Myers Squibb, personal fees and other from Bayer, other from Novo Nordisk, personal fees and other from Pfizer, personal fees from Novartis. A.G. declares a conflict outside of the submitted work: personal fees and non-financial support from Maco Pharma, Boehringer Ingelheim, personal fees from ASPEN, personal fees from Bristol Myers Squibb, other from Bayer Healthcare, grants and other from Instrumentation laboratories.