Pericardial fluids or Cardiopulmonary Bypass-Is There a Major Culprit for Changes in Coagulation and Inflammation?
Aged
Antithrombin III
Biomarkers
/ blood
Blood Coagulation
Cardiopulmonary Bypass
/ adverse effects
Coronary Artery Bypass
/ adverse effects
Female
Fibrin Fibrinogen Degradation Products
/ metabolism
Germany
Humans
Inflammation Mediators
/ blood
Male
Middle Aged
Operative Blood Salvage
/ adverse effects
Peptide Hydrolases
/ blood
Pericardial Fluid
/ metabolism
Risk Factors
Suction
Time Factors
Treatment Outcome
Journal
The Thoracic and cardiovascular surgeon
ISSN: 1439-1902
Titre abrégé: Thorac Cardiovasc Surg
Pays: Germany
ID NLM: 7903387
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
7
2
2019
medline:
22
9
2020
entrez:
7
2
2019
Statut:
ppublish
Résumé
From the results of a previous study, it remained to be investigated if a perioperative rise of few tested coagulation and inflammation markers is caused by conventional cardiopulmonary bypass (CPB) itself or rather by direct recirculation of pericardial fluids. Forty-eight patients operated on with conventional CPB for myocardial revascularization were randomized either for direct recirculation of pericardial suction fluids or for cell saving (CS). Thrombin-antithrombin complexes showed lower values intraoperatively in the CS group ( Direct recirculation of pericardial fluids rather than conventional CPB itself causes major intraoperative changes of some coagulation markers. Pericardial blood loss with direct recirculation should be kept to a minimum to avoid unnecessary activation of coagulation. Inflammation markers need further investigations.
Sections du résumé
BACKGROUND
From the results of a previous study, it remained to be investigated if a perioperative rise of few tested coagulation and inflammation markers is caused by conventional cardiopulmonary bypass (CPB) itself or rather by direct recirculation of pericardial fluids.
METHODS
Forty-eight patients operated on with conventional CPB for myocardial revascularization were randomized either for direct recirculation of pericardial suction fluids or for cell saving (CS).
RESULTS
Thrombin-antithrombin complexes showed lower values intraoperatively in the CS group (
CONCLUSION
Direct recirculation of pericardial fluids rather than conventional CPB itself causes major intraoperative changes of some coagulation markers. Pericardial blood loss with direct recirculation should be kept to a minimum to avoid unnecessary activation of coagulation. Inflammation markers need further investigations.
Identifiants
pubmed: 30727012
doi: 10.1055/s-0039-1677836
doi:
Substances chimiques
Biomarkers
0
Fibrin Fibrinogen Degradation Products
0
Inflammation Mediators
0
antithrombin III-protease complex
0
fibrin fragment D
0
Antithrombin III
9000-94-6
Peptide Hydrolases
EC 3.4.-
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
219-222Informations de copyright
Georg Thieme Verlag KG Stuttgart · New York.
Déclaration de conflit d'intérêts
The authors have no disclosure or conflict of interest.