Promoters to Study Vascular Smooth Muscle.

Actins / biosynthesis Animals Cell Line Cell Lineage Cell Transdifferentiation Gene Expression Regulation Gene Knockout Techniques Gene Targeting / methods Humans Mice Microfilament Proteins / biosynthesis Muscle Proteins / biosynthesis Muscle, Smooth, Vascular / physiology Myocytes, Smooth Muscle / physiology Myofibroblasts / physiology Myosin Heavy Chains / biosynthesis Neovascularization, Pathologic / physiopathology Neovascularization, Physiologic Phenotype Promoter Regions, Genetic Recombinant Fusion Proteins / metabolism
atherosclerosis gene expression mice, transgenic muscle, smooth myeloid cells neointima

Journal

Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803

Informations de publication

Date de publication:
04 2019
Historique:
pubmed: 8 2 2019
medline: 14 1 2020
entrez: 8 2 2019
Statut: ppublish

Résumé

Smooth muscle cells (SMCs) are a critical component of blood vessel walls that provide structural support, regulate vascular tone, and allow for vascular remodeling. These cells also exhibit a remarkable plasticity that contributes to vascular growth and repair but also to cardiovascular pathologies, including atherosclerosis, intimal hyperplasia and restenosis, aneurysm, and transplant vasculopathy. Mouse models have been an important tool for the study of SMC functions. The development of smooth muscle-expressing Cre-driver lines has allowed for exciting discoveries, including recent advances revealing the diversity of phenotypes derived from mature SMC transdifferentiation in vivo using inducible CreER

Identifiants

DOI: 10.1161/ATVBAHA.119.312449 PMID: 30727757 PMC: PMC6527360
pubmed: 30727757
doi: 10.1161/ATVBAHA.119.312449
pmc: PMC6527360
mid: NIHMS1519765
doi:

Substances chimiques

Acta2 protein, mouse 0
Actins 0
Microfilament Proteins 0
Muscle Proteins 0
Recombinant Fusion Proteins 0
Tagln protein, mouse 0
myosin 11, mouse 0
Myosin Heavy Chains EC 3.6.4.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

603-612

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL118430
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL125815
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142674
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG062202
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133016
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL146101
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL142090
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL091013
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119529
Pays : United States

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Auteurs

Raja Chakraborty (R)

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).

Fatima Zahra Saddouk (FZ)

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).
Department of Genetics (F.Z.S., D.M.G.).

Ana Catarina Carrao (AC)

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).

Diane S Krause (DS)

Departments of Laboratory Medicine, Cell Biology, and Pathology (D.S.K.).

Daniel M Greif (DM)

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).
Department of Genetics (F.Z.S., D.M.G.).

Kathleen A Martin (KA)

From the Department of Medicine, Section of Cardiovascular Medicine (R.C., F.Z.S., A.C.C., D.M.G., K.A.M.).
Department of Pharmacology (K.A.M.), Yale University School of Medicine, New Haven, CT.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Eucaryotes › Animaux › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines contractiles › Protéines du muscle › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Tissus › Muscles › Muscles lisses › Muscles lisses vasculaires › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Myofibroblastes › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Myosines › Chaînes lourdes de myosine › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Métaplasie › Néovascularisation pathologique › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Promoters to Study Vascular Smooth Muscle.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines recombinantes › Protéines de fusion recombinantes › Promoters to Study Vascular Smooth Muscle.