Immune-Checkpoint Blockade Opposes CD8
Animals
Antibodies, Blocking
/ pharmacology
CD8-Positive T-Lymphocytes
/ drug effects
Cell Proliferation
Disease Models, Animal
Head and Neck Neoplasms
/ immunology
Hepatitis A Virus Cellular Receptor 2
/ immunology
Humans
Immunotherapy
Interleukin-10
/ immunology
Interleukin-7
/ pharmacology
Ligands
Lymphocytes, Tumor-Infiltrating
/ drug effects
Mice
Programmed Cell Death 1 Receptor
/ immunology
Squamous Cell Carcinoma of Head and Neck
/ immunology
Tumor Microenvironment
/ immunology
Journal
Cancer immunology research
ISSN: 2326-6074
Titre abrégé: Cancer Immunol Res
Pays: United States
ID NLM: 101614637
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
01
02
2018
revised:
14
11
2018
accepted:
01
02
2019
pubmed:
8
2
2019
medline:
21
5
2020
entrez:
8
2
2019
Statut:
ppublish
Résumé
Immune-checkpoint blockade enhances antitumor responses against cancers. One cancer type that is sensitive to checkpoint blockade is squamous cell carcinoma of the head and neck (SCCHN), which we use here to study limitations of this treatment modality. We observed that CD8
Identifiants
pubmed: 30728151
pii: 2326-6066.CIR-18-0054
doi: 10.1158/2326-6066.CIR-18-0054
pmc: PMC6476322
mid: NIHMS1521055
doi:
Substances chimiques
Antibodies, Blocking
0
Hepatitis A Virus Cellular Receptor 2
0
Interleukin-7
0
Ligands
0
Programmed Cell Death 1 Receptor
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
510-525Subventions
Organisme : NCI NIH HHS
ID : R01 CA132796
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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