The "Guardian of the Genome"-An Old Key to Unlock the ERCC1 Issue.

Cisplatin DNA Adducts DNA Repair

Journal

Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500

Informations de publication

Date de publication:
15 04 2019
Historique:
received: 09 01 2019
revised: 22 01 2019
accepted: 31 01 2019
pubmed: 8 2 2019
medline: 4 7 2019
entrez: 8 2 2019
Statut: ppublish

Résumé

Excision Repair Cross-Complementation Group 1 (ERCC1) participates in the repair of DNA intrastrand adducts (ISA) and interstrand cross-links, but its role as a predictive biomarker has never been fully validated. It has now been revealed that p53 mutation status should be considered concomitantly with ERCC1 to predict cisplatin efficacy.

Identifiants

DOI: 10.1158/1078-0432.CCR-18-4123 PMID: 30728154
pubmed: 30728154
pii: 1078-0432.CCR-18-4123
doi: 10.1158/1078-0432.CCR-18-4123
doi:

Substances chimiques

DNA Adducts 0
Cisplatin Q20Q21Q62J

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

2369-2371

Commentaires et corrections

Type : CommentOn

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Luc Friboulet (L)

INSERM U981, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France.

Jean-Charles Soria (JC)

Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France.

Ken André Olaussen (KA)

INSERM U981, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. ken.olaussen@gustaveroussy.fr.
Université Paris-Sud, Faculté de Médecine, Le Kremlin-Bicêtre, France.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés du platine › Cisplatine › The "Guardian of the Genome"-An Old Key to...
questionsmedicales.fr › Phénomènes génétiques › Altération de l'ADN › Adduits à l'ADN › The "Guardian of the Genome"-An Old Key to...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › The "Guardian of the Genome"-An Old Key to...