International Consensus on Risk Management of Diabetic Ketoacidosis in Patients With Type 1 Diabetes Treated With Sodium-Glucose Cotransporter (SGLT) Inhibitors.


Journal

Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975

Informations de publication

Date de publication:
Jun 2019
Historique:
pubmed: 8 2 2019
medline: 4 7 2019
entrez: 8 2 2019
Statut: ppublish

Résumé

Sodium-glucose cotransporter (SGLT) inhibitors are new oral antidiabetes medications shown to effectively reduce glycated hemoglobin (A1C) and glycemic variability, blood pressure, and body weight without intrinsic properties to cause hypoglycemia in people with type 1 diabetes. However, recent studies, particularly in individuals with type 1 diabetes, have demonstrated increases in the absolute risk of diabetic ketoacidosis (DKA). Some cases presented with near-normal blood glucose levels or mild hyperglycemia, complicating the recognition/diagnosis of DKA and potentially delaying treatment. Several SGLT inhibitors are currently under review by the U.S. Food and Drug Administration and European regulatory agencies as adjuncts to insulin therapy in people with type 1 diabetes. Strategies must be developed and disseminated to the medical community to mitigate the associated DKA risk. This Consensus Report reviews current data regarding SGLT inhibitor use and provides recommendations to enhance the safety of SGLT inhibitors in people with type 1 diabetes.

Identifiants

pubmed: 30728224
pii: dc18-2316
doi: 10.2337/dc18-2316
pmc: PMC6973545
doi:

Substances chimiques

Hypoglycemic Agents 0
Sodium-Glucose Transporter 2 Inhibitors 0
Sodium 9NEZ333N27
Glucose IY9XDZ35W2

Types de publication

Journal Article Review Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1147-1154

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentOn

Informations de copyright

© 2019 by the American Diabetes Association.

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Auteurs

Thomas Danne (T)

Diabetes Centre for Children and Adolescents, Kinder- und Jugendkrankenhaus Auf der Bult, Hannover, Germany.

Satish Garg (S)

University of Colorado Denver and Barbara Davis Center for Diabetes, Aurora, CO.

Anne L Peters (AL)

Keck School of Medicine of the University of Southern California, Los Angeles, CA.

John B Buse (JB)

University of North Carolina School of Medicine, Chapel Hill, NC.

Chantal Mathieu (C)

Department of Endocrinology, UZ Gasthuisberg, KU Leuven, Leuven, Belgium.

Jeremy H Pettus (JH)

Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA.

Charles M Alexander (CM)

Alexander Associates LLC, Gwynedd Valley, PA.

Tadej Battelino (T)

Department of Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital, University Medical Centre Ljubljana, and Faculty of Medicine, University of Ljubljana, Slovenia.

F Javier Ampudia-Blasco (FJ)

Clinic University Hospital of Valencia, Valencia, Spain.

Bruce W Bode (BW)

Atlanta Diabetes Associates, Atlanta, GA.

Bertrand Cariou (B)

Clinique d'endocrinologie, L'institut du thorax, CHU Nantes, CIC 1413 INSERM, Nantes, France.

Kelly L Close (KL)

The diaTribe Foundation, San Francisco, CA.

Paresh Dandona (P)

Division of Endocrinology, Diabetes and Metabolism, University at Buffalo, The State University of New York, Buffalo, NY.

Sanjoy Dutta (S)

JDRF International, New York, NY.

Ele Ferrannini (E)

National Research Council (CNR) Institute of Clinical Physiology, Pisa, Italy.

Spiros Fourlanos (S)

Department of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Australia.

George Grunberger (G)

Grunberger Diabetes Institute, Bloomfield Hills, MI.

Simon R Heller (SR)

Academic Unit of Diabetes, Endocrinology & Metabolism, University of Sheffield, Sheffield, U.K.

Robert R Henry (RR)

Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA.

Martin J Kurian (MJ)

Close Concerns, San Francisco, CA.

Jake A Kushner (JA)

McNair Interests, Houston, TX.

Tal Oron (T)

Jesse Z and Sara Lea Shafer Institute of Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Christopher G Parkin (CG)

CGParkin Communications, Inc., Boulder City, NV chris@cgparkin.org.

Thomas R Pieber (TR)

Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Helena W Rodbard (HW)

Endocrine and Metabolic Consultants, Rockville, MD.

Desmond Schatz (D)

Division of Endocrinology, Department of Pediatrics, University of Florida, Gainesville, FL.

Jay S Skyler (JS)

Division of Endocrinology, Diabetes and Metabolism, Miller School of Medicine, University of Miami, Miami, FL.

William V Tamborlane (WV)

Department of Pediatrics, Yale School of Medicine, New Haven, CT.

Koutaro Yokote (K)

Department of Diabetes, Metabolism and Endocrinology, Chiba University Graduate School of Medicine, Chiba, Japan.

Moshe Phillip (M)

Jesse Z and Sara Lea Shafer Institute of Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

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