Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer.
Animals
Antibodies, Monoclonal
/ metabolism
Biomass
CD36 Antigens
/ metabolism
Cell Line, Tumor
Disease Models, Animal
Disease Progression
Epithelial Cells
/ metabolism
Fatty Acids
/ metabolism
Gene Deletion
Gene Silencing
Humans
Lipid Metabolism
Male
Mice
Neoplasm Invasiveness
PTEN Phosphohydrolase
/ deficiency
Prostate
/ metabolism
Prostatic Neoplasms
/ drug therapy
RNA, Small Interfering
/ metabolism
Tumor Burden
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
06 02 2019
06 02 2019
Historique:
received:
25
06
2018
revised:
17
09
2018
accepted:
15
01
2019
entrez:
8
2
2019
pubmed:
8
2
2019
medline:
23
2
2020
Statut:
ppublish
Résumé
Metabolism alterations are hallmarks of cancer, but the involvement of lipid metabolism in disease progression is unclear. We investigated the role of lipid metabolism in prostate cancer using tissue from patients with prostate cancer and patient-derived xenograft mouse models. We showed that fatty acid uptake was increased in human prostate cancer and that these fatty acids were directed toward biomass production. These changes were mediated, at least partly, by the fatty acid transporter CD36, which was associated with aggressive disease. Deleting
Identifiants
pubmed: 30728288
pii: 11/478/eaau5758
doi: 10.1126/scitranslmed.aau5758
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
CD36 Antigens
0
Fatty Acids
0
RNA, Small Interfering
0
PTEN Phosphohydrolase
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.