Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Animals Cell Line, Tumor Cell Membrane / metabolism Cell Proliferation Fatty Acid Desaturases / metabolism Fatty Acids / chemistry Female HEK293 Cells Humans Male Metabolic Networks and Pathways Mice Neoplasms / metabolism Oleic Acids / metabolism Palmitates / metabolism Palmitic Acids / metabolism Stearoyl-CoA Desaturase / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2019
Historique:
received: 08 12 2017
accepted: 20 12 2018
pubmed: 8 2 2019
medline: 14 8 2019
entrez: 8 2 2019
Statut: ppublish

Résumé

Most tumours have an aberrantly activated lipid metabolism

Identifiants

DOI: 10.1038/s41586-019-0904-1 PMID: 30728499 PMC: PMC6390935
pubmed: 30728499
doi: 10.1038/s41586-019-0904-1
pii: 10.1038/s41586-019-0904-1
pmc: PMC6390935
mid: EMS80980
doi:

Substances chimiques

Fatty Acids 0
Oleic Acids 0
Palmitates 0
Palmitic Acids 0
delta(6)-hexadecenoic acid 0
Fatty Acid Desaturases EC 1.14.19.-
Stearoyl-CoA Desaturase EC 1.14.19.1
FADS2 protein, human EC 1.14.19.3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

403-406

Subventions

Organisme : NCI NIH HHS
ID : R35 CA220449
Pays : United States
Organisme : NCI NIH HHS
ID : R35CA22044901
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Références

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Auteurs

Kim Vriens (K)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Stefan Christen (S)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Sweta Parik (S)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.
Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium.

Dorien Broekaert (D)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Kazuaki Yoshinaga (K)

Tsukishima Foods Industry, Tokyo, Japan.
Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan.

Ali Talebi (A)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.

Jonas Dehairs (J)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.

Carmen Escalona-Noguero (C)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Roberta Schmieder (R)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Thomas Cornfield (T)

The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.

Catriona Charlton (C)

The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.

Laura Romero-Pérez (L)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Matteo Rossi (M)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Gianmarco Rinaldi (G)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Martin F Orth (MF)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.

Ruben Boon (R)

Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Axelle Kerstens (A)

VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.
Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium.

Suet Ying Kwan (SY)

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Brandon Faubert (B)

Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.

Andrés Méndez-Lucas (A)

The Francis Crick Institute, London, UK.

Charlotte C Kopitz (CC)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Ting Chen (T)

Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA.

Juan Fernandez-Garcia (J)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

João A G Duarte (JAG)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.

Arndt A Schmitz (AA)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Patrick Steigemann (P)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Mustapha Najimi (M)

Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium.

Andrea Hägebarth (A)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Jo A Van Ginderachter (JA)

Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium.

Etienne Sokal (E)

Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium.

Naohiro Gotoh (N)

Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.

Kwok-Kin Wong (KK)

Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA.

Catherine Verfaillie (C)

Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Rita Derua (R)

Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Sebastian Munck (S)

VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.
Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium.

Mariia Yuneva (M)

The Francis Crick Institute, London, UK.

Laura Beretta (L)

Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Ralph J DeBerardinis (RJ)

Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.
Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.

Johannes V Swinnen (JV)

Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium.

Leanne Hodson (L)

The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK.

David Cassiman (D)

Department of Hepatology, KU Leuven, Leuven, Belgium.
Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium.

Chris Verslype (C)

Department of Hepatology, KU Leuven, Leuven, Belgium.
Department of Digestive Oncology, KU Leuven, Leuven, Belgium.

Sven Christian (S)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Sylvia Grünewald (S)

Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany.

Thomas G P Grünewald (TGP)

Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.
German Cancer Research Center (DKFZ), Heidelberg, Germany.

Sarah-Maria Fendt (SM)

Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be.
Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Evidence for an alternative fatty acid...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Evidence for an alternative fatty acid...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Evidence for an alternative fatty acid...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Evidence for an alternative fatty acid...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Evidence for an alternative fatty acid...
questionsmedicales.fr › Lipides › Acides gras › Evidence for an alternative fatty acid...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Evidence for an alternative fatty acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evidence for an alternative fatty acid...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Evidence for an alternative fatty acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Evidence for an alternative fatty acid...
questionsmedicales.fr › Tumeurs › Evidence for an alternative fatty acid...
questionsmedicales.fr › Lipides › Acides gras › Acides gras insaturés › Acides gras monoinsaturés › Acides oléiques › Evidence for an alternative fatty acid...
questionsmedicales.fr › Lipides › Acides gras › Acides palmitiques › Palmitates › Evidence for an alternative fatty acid...
questionsmedicales.fr › Lipides › Acides gras › Acides palmitiques › Evidence for an alternative fatty acid...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Fatty acid desaturases › Acyl-(acyl-carrier-protein)desaturase › Evidence for an alternative fatty acid...