White-matter-nulled MPRAGE at 7T reveals thalamic lesions and atrophy of specific thalamic nuclei in multiple sclerosis.
Adult
Atlases as Topic
Atrophy
/ pathology
Female
Humans
Image Interpretation, Computer-Assisted
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Multiple Sclerosis
/ diagnostic imaging
Neuroimaging
/ methods
Thalamic Nuclei
/ diagnostic imaging
White Matter
/ diagnostic imaging
Thalamic nuclei
multi-atlas segmentation
multiple sclerosis
ultra-high field magnetic resonance imaging
white-matter-nulled MPRAGE
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
8
2
2019
medline:
29
7
2021
entrez:
8
2
2019
Statut:
ppublish
Résumé
Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging. White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients ( WMn-MPRAGE showed more thalamic MS lesions ( WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy.
Sections du résumé
BACKGROUND
Investigating the degeneration of specific thalamic nuclei in multiple sclerosis (MS) remains challenging.
METHODS
White-matter-nulled (WMn) MPRAGE, MP-FLAIR, and standard T1-weighted magnetic resonance imaging (MRI) were performed on MS patients (
RESULTS
WMn-MPRAGE showed more thalamic MS lesions (
CONCLUSION
WMn-MPRAGE and automatic thalamic segmentation can highlight thalamic MS lesions and measure patterns of focal thalamic atrophy.
Identifiants
pubmed: 30730233
doi: 10.1177/1352458519828297
pmc: PMC6685761
mid: NIHMS1518662
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
987-992Subventions
Organisme : NIBIB NIH HHS
ID : P41 EB015891
Pays : United States
Références
Cell Mol Life Sci. 2015 Mar;72(6):1127-47
pubmed: 25417212
Mult Scler. 2018 Oct;24(11):1433-1444
pubmed: 28803512
Magn Reson Med. 2015 May;73(5):1786-94
pubmed: 24889754
Hum Brain Mapp. 2015 Jul;36(7):2809-25
pubmed: 25873194
Brain Struct Funct. 2017 Jul;222(5):2203-2216
pubmed: 27888345
Mult Scler. 2015 Aug;21(9):1139-50
pubmed: 25583851
Hum Brain Mapp. 2018 Apr;39(4):1814-1824
pubmed: 29331060
Invest Radiol. 2014 May;49(5):290-8
pubmed: 24566291
Mult Scler. 2016 Sep;22(10):1327-36
pubmed: 26541795
Neuroimage. 2004 Apr;21(4):1428-42
pubmed: 15050568
Radiology. 2015 Dec;277(3):784-92
pubmed: 26043265
Neuroimage. 2014 Jan 1;84:534-45
pubmed: 24018302
Neurology. 2013 Jan 8;80(2):210-9
pubmed: 23296131