Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.
Adenosine Triphosphatases
/ antagonists & inhibitors
Adenoviridae
Animals
Benzylamines
/ pharmacology
Calcium
/ metabolism
Cardiomyopathy, Hypertrophic
/ genetics
Guinea Pigs
In Vitro Techniques
Male
Mutation
Myocytes, Cardiac
/ metabolism
Myofibrils
/ drug effects
Myosins
/ drug effects
Sarcomeres
/ metabolism
Simendan
/ pharmacology
Transduction, Genetic
/ methods
Troponin I
/ genetics
Troponin T
/ genetics
Uracil
/ analogs & derivatives
Urea
/ analogs & derivatives
calcium
cardiomyopathies
fluorescence
mutation
sarcomere
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
12 04 2019
12 04 2019
Historique:
pubmed:
9
2
2019
medline:
24
1
2020
entrez:
9
2
2019
Statut:
ppublish
Résumé
Subcellular Ca To produce and validate myofilament-restricted Ca When expressed in adult ventricular cardiomyocytes RGECO-TnT (Troponin T)/TnI (Troponin I) sensors localize correctly to the sarcomere without contractile impairment. Both sensors report cyclical changes in fluorescence in paced cardiomyocytes with reduced Ca RGECO-TnT/TnI are functionally equivalent. They visualize Ca
Identifiants
pubmed: 30732532
doi: 10.1161/CIRCRESAHA.118.314600
pmc: PMC6485313
mid: EMS81776
doi:
Substances chimiques
Benzylamines
0
MYK-461
0
Troponin I
0
Troponin T
0
omecamtiv mecarbil
2M19539ERK
Simendan
349552KRHK
Uracil
56HH86ZVCT
Urea
8W8T17847W
Adenosine Triphosphatases
EC 3.6.1.-
Myosins
EC 3.6.4.1
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1228-1239Subventions
Organisme : Wellcome Trust
ID : 098519
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/1/30181
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/18/68/33883
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/9/33887
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/12/16/29939
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/08/004/23915
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
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