Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Animals
CD4-Positive T-Lymphocytes
/ enzymology
CD8-Positive T-Lymphocytes
/ enzymology
Cell Movement
Choline O-Acetyltransferase
/ genetics
Female
Interleukins
/ immunology
Lymphocyte Activation
Lymphocytic Choriomeningitis
/ immunology
Lymphocytic choriomeningitis virus
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Vasodilation
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
08 02 2019
08 02 2019
Historique:
received:
26
07
2018
accepted:
14
12
2018
entrez:
9
2
2019
pubmed:
9
2
2019
medline:
6
8
2019
Statut:
ppublish
Résumé
Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4
Identifiants
pubmed: 30733420
pii: 363/6427/639
doi: 10.1126/science.aau9072
pmc: PMC7181845
mid: NIHMS1583905
doi:
Substances chimiques
Interleukins
0
Choline O-Acetyltransferase
EC 2.3.1.6
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
639-644Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118182
Pays : United States
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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