A Practical Guide to Treatment of Childhood Absence Epilepsy.
Anticonvulsants
/ therapeutic use
Child
Child, Preschool
Drug-Related Side Effects and Adverse Reactions
Electroencephalography
Epilepsy, Absence
/ diagnosis
Ethosuximide
/ therapeutic use
Female
Humans
Lamotrigine
/ therapeutic use
Male
Practice Guidelines as Topic
Seizures
/ drug therapy
Treatment Outcome
Valproic Acid
/ therapeutic use
Journal
Paediatric drugs
ISSN: 1179-2019
Titre abrégé: Paediatr Drugs
Pays: Switzerland
ID NLM: 100883685
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
pubmed:
9
2
2019
medline:
2
4
2019
entrez:
9
2
2019
Statut:
ppublish
Résumé
Childhood absence epilepsy (CAE) is a common pediatric epilepsy syndrome with distinct seizure semiology, electroencephalography (EEG) features, and treatment. A diagnosis of CAE can be obtained during an office visit with a careful history, physical exam including prolonged hyperventilation, and a routine EEG. The treatment of choice for CAE with absence seizures only is ethosuximide. Valproic acid and lamotrigine are also effective treatments for many patients, but when compared to ethosuximide, valproic acid has more adverse effects and lamotrigine is less effective. Attention to predictors of response to treatment, including clinical, electrographic, and genetic factors, is increasing. Refractory CAE occurs in fewer than half of patients, and treatment strategies are available, though efficacy data are lacking. Careful assessment and treatment of psychosocial comorbidities is essential in caring for patients with CAE.
Identifiants
pubmed: 30734897
doi: 10.1007/s40272-019-00325-x
pii: 10.1007/s40272-019-00325-x
pmc: PMC6394437
doi:
Substances chimiques
Anticonvulsants
0
Ethosuximide
5SEH9X1D1D
Valproic Acid
614OI1Z5WI
Lamotrigine
U3H27498KS
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-24Références
Pharmacotherapy. 1999 Apr;19(4):437-41
pubmed: 10212015
Epilepsia. 1999 Jul;40(7):973-9
pubmed: 10403222
Epilepsia. 2000 Jul;41(7):802-10
pubmed: 10897150
Epilepsia. 2001 Jun;42(6):760-3
pubmed: 11422332
Seizure. 2002 Sep;11(6):406-10
pubmed: 12160672
Epilepsy Res. 2005 Mar-Apr;64(1-2):31-4
pubmed: 15847848
Epilepsia. 2005 Nov;46(11):1796-801
pubmed: 16302860
J Child Neurol. 2005 Dec;20 Suppl 1:S1-56; quiz S59-60
pubmed: 16615562
Neurology. 2006 Aug 8;67(3):413-8
pubmed: 16894100
Epilepsia. 2007 Jul;48(7):1223-44
pubmed: 17386054
Epilepsia. 1991;32 Suppl 5:S74-9
pubmed: 1743173
Neurology. 2007 May 15;68(20):1701-9
pubmed: 17502552
Epilepsia. 2008 Nov;49(11):1838-46
pubmed: 18557780
Epilepsy Res. 2008 Dec;82(2-3):124-32
pubmed: 18778916
Dev Med Child Neurol. 2008 Nov;50(11):850-3
pubmed: 18808424
Epilepsy Res. 2009 Feb;83(2-3):249-56
pubmed: 19124226
Epilepsia. 2009 Aug;50(8):2003
pubmed: 19682032
Epilepsia. 2009 Sep;50 Suppl 8:31-6
pubmed: 19702731
N Engl J Med. 2010 Mar 4;362(9):790-9
pubmed: 20200383
Acta Neurol Scand. 2011 Jan;123(1):54-9
pubmed: 20219018
J Child Neurol. 2011 Feb;26(2):160-5
pubmed: 20647578
Epilepsia. 2011 Apr;52(4):802-9
pubmed: 21320119
Eur J Paediatr Neurol. 2011 Nov;15(6):508-11
pubmed: 21680209
CNS Drugs. 2012 Mar 1;26(3):229-44
pubmed: 22145708
Epilepsia. 2012 Mar;53(3):e55-9
pubmed: 22310062
Eur J Paediatr Neurol. 2012 Nov;16(6):599-604
pubmed: 22398177
Drug Healthc Patient Saf. 2012;4:39-54
pubmed: 22792008
J Child Neurol. 2013 Jan;28(1):34-9
pubmed: 23112242
Epilepsia. 2013 Jan;54(1):141-55
pubmed: 23167925
Neurology. 2013 Jul 9;81(2):150-6
pubmed: 23719147
Neurology. 2013 Oct 29;81(18):1572-80
pubmed: 24089388
Epilepsia. 2014 Apr;55(4):551-7
pubmed: 24512528
Pediatr Neurol. 2014 Jul;51(1):60-6
pubmed: 24830765
Brain. 1989 Aug;112 ( Pt 4):1039-56
pubmed: 2505885
Ann Neurol. 1989 Jun;25(6):582-93
pubmed: 2545161
Epilepsia. 2015 Jul;56(7):1006-19
pubmed: 25851171
Epilepsia. 2015 Dec;56(12):e203-8
pubmed: 26537434
Neurology. 2017 Jan 10;88(2):182-190
pubmed: 27986874
Ann Neurol. 2017 Mar;81(3):444-453
pubmed: 28165634
Neurology. 2017 Aug 15;89(7):673-679
pubmed: 28724582
Neurology. 2017 Oct 17;89(16):1698-1706
pubmed: 28916534
Drugs R D. 2018 Mar;18(1):1-5
pubmed: 29260458
Neurology. 2018 Jul 10;91(2):74-81
pubmed: 29898971
Ann Neurol. 1987 Mar;21(3):268-73
pubmed: 3111345
J Pharmacol Exp Ther. 1988 Dec;247(3):1128-32
pubmed: 3144596
Neurology. 1986 Jun;36(6):838-41
pubmed: 3703292
Clin Pharmacokinet. 1979 Jan-Feb;4(1):38-52
pubmed: 421410
J Clin Pharmacol J New Drugs. 1969 Nov-Dec;9(6):393-8
pubmed: 5260202
Epilepsia. 1984;25 Suppl 1:S1-4
pubmed: 6325139
Ann Neurol. 1983 Jun;13(6):642-8
pubmed: 6410975
Neurology. 1983 Dec;33(12):1590-5
pubmed: 6417557
Epilepsia. 1995 Dec;36(12):1182-6
pubmed: 7489694
Neurology. 1995 Aug;45(8):1469-76
pubmed: 7644043
Clin Pharmacokinet. 1993 Dec;25(6):433-43
pubmed: 8119045
Epilepsia. 1994 Mar-Apr;35(2):359-67
pubmed: 8156958
Ann Neurol. 1994 May;35(5):534-45
pubmed: 8179299
Neurology. 1976 Aug;26(8):788-96
pubmed: 821006
Clin Pharmacokinet. 1995 Oct;29(4):257-86
pubmed: 8549027
Pediatr Neurol. 1996 Apr;14(3):199-202
pubmed: 8736402
Neurology. 1996 Oct;47(4):912-8
pubmed: 8857718
Arch Pediatr Adolesc Med. 1997 Feb;151(2):152-8
pubmed: 9041870
J Child Neurol. 1996 Nov;11(6):470-5
pubmed: 9120226
Epilepsy Res. 1997 Mar;26(3):423-32
pubmed: 9127723
J Pediatr. 1998 Nov;133(5):660-3
pubmed: 9821425