Polysomnographic Analysis of a Pediatric Case of Baclofen-Induced Central Sleep Apnea.
baclofen
pediatric
polysomnography
rehabilitation
sleep-disordered breathing
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
07
08
2018
accepted:
26
10
2018
pubmed:
10
2
2019
medline:
21
7
2020
entrez:
10
2
2019
Statut:
epublish
Résumé
Respiratory disorders may follow brain injury and may also occur because of comorbidities and drug use, especially central depressants or muscle relaxants. Sleep can precipitate respiratory disorders, thus polysomnography can be a powerful diagnostic tool. By revealing breathing patterns that identify specific sleep disorders, polysomnography may unmask adverse pharmacological effects, for instance connecting central depressant drugs with central sleep apneas. We describe the case of a pediatric patient in rehabilitation from brain injury who developed a central sleep apnea following a baclofen dose increase within the therapeutic range, while assuming an under-dosed benzodiazepine. Polysomnography identified a typical respiration pattern, previously observed in adults treated with baclofen and other central depressants. Baclofen tapering resolved the central sleep apnea. Polysomnography, and this specific pattern, may be proposed as diagnostic tools in patients with high dose baclofen that can be used to prevent potential respiratory disorders in children.
Identifiants
pubmed: 30736882
doi: 10.5664/jcsm.7644
pii: jc-18-00483
pmc: PMC6374087
doi:
Substances chimiques
Baclofen
H789N3FKE8
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
351-354Informations de copyright
© 2019 American Academy of Sleep Medicine.
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