The role of age in treatment-related adverse events in patients with head and neck cancer: A systematic review.
Age Factors
Aged
Carcinoma, Squamous Cell
/ mortality
Combined Modality Therapy
/ adverse effects
Comorbidity
Enhanced Recovery After Surgery
Frailty
Geriatric Assessment
Head and Neck Neoplasms
/ mortality
Humans
Neoplasm Metastasis
Neoplasm Recurrence, Local
Operative Time
Patient Selection
Postoperative Complications
Prognosis
Social Support
adverse events
comorbidity
elderly
head and neck cancer
postoperative complications
prognosis
toxicity
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
08
04
2018
revised:
03
01
2019
accepted:
24
01
2019
pubmed:
10
2
2019
medline:
18
11
2020
entrez:
10
2
2019
Statut:
ppublish
Résumé
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed in advanced stage and therefore requires aggressive, multimodal treatment. Elderly patients are often excluded from standard therapy regimens purely based on age. This clinical review aims to collect all published data in the literature on treatment modality selection in elderly patients and on age-related adverse events following treatment of HNSCC. We performed a literature search for articles on the treatment of HNSCC in elderly patients. Most of the articles were retrospective studies with the consequent limitations. It can be concluded that age is not an absolute contraindication for intensive treatment and comorbidity is an important predictor of outcome, but not the only one. Despite the existence of multiple tools for pretreatment evaluation, there are not consistent data on their use.
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2410-2429Informations de copyright
© 2019 Wiley Periodicals, Inc.