Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte.
Endoplasmic Reticulum Stress
/ drug effects
Fatty Acids
/ chemistry
Fatty Liver
/ chemically induced
Hep G2 Cells
Hepatocytes
/ drug effects
Humans
Insecticides
/ pharmacology
Ivermectin
/ pharmacology
Lipogenesis
/ drug effects
Oxidation-Reduction
Palmitic Acid
Permethrin
/ pharmacology
Triglycerides
/ metabolism
HepG2
Ivermectin
NAFLD
Permethrin
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
30
08
2018
revised:
09
01
2019
accepted:
04
02
2019
pubmed:
10
2
2019
medline:
21
5
2019
entrez:
10
2
2019
Statut:
ppublish
Résumé
Recent studies have reported the positive association between exposure to insecticides and increased risk of obesity and type 2 diabetes, which are closely associated with non-alcoholic fatty liver disease (NAFLD). However, it is not known if insecticide exposure can contribute to NAFLD. Thus, the goal of the current study was to determine if insecticide exposures can exacerbate the physiological conditions of NAFLD by modulating hepatic lipid metabolism. The effects of 12 insecticides on triglycerides (TG) accumulation were tested using palmitic acid (PA)-induced HepG2 hepatoma steatosis model. Results showed that among tested insecticides, permethrin and ivermectin significant interacted with palmitic acid to potentiate (permethrin) or decrease (ivermectin) TG accumulation. Further study showed that permethrin significantly promoted fatty acid synthesis, while suppressed lipid oxidation-related genes only under steatosis conditions. In comparison, ivermectin inhibited lipogenesis-related genes and promoted farnesoid X receptor, which upregulates fatty acid oxidation. Results in this study suggested that hepatic lipid metabolism may be more susceptible to insecticide exposure in the presence of excessive fatty acids, which can be associated with the development of NAFLD.
Identifiants
pubmed: 30738135
pii: S0278-6915(19)30055-9
doi: 10.1016/j.fct.2019.02.005
pmc: PMC6527113
mid: NIHMS1521613
pii:
doi:
Substances chimiques
Fatty Acids
0
Insecticides
0
Triglycerides
0
Palmitic Acid
2V16EO95H1
Permethrin
509F88P9SZ
Ivermectin
70288-86-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-604Subventions
Organisme : NIEHS NIH HHS
ID : R21 ES023676
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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