Impact of Degree of Left Ventricular Remodeling on Clinical Outcomes From Cardiac Resynchronization Therapy.
Aged
Cardiac Resynchronization Therapy
/ methods
Defibrillators, Implantable
Echocardiography
Female
Follow-Up Studies
Heart Failure
/ diagnosis
Heart Ventricles
/ diagnostic imaging
Humans
Male
Middle Aged
Retrospective Studies
Stroke Volume
/ physiology
Treatment Outcome
Ventricular Function, Left
/ physiology
Ventricular Remodeling
CRT
eccentric remodeling
left ventricular diastolic dimension
Journal
JACC. Heart failure
ISSN: 2213-1787
Titre abrégé: JACC Heart Fail
Pays: United States
ID NLM: 101598241
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
30
07
2018
revised:
05
11
2018
accepted:
05
11
2018
pubmed:
11
2
2019
medline:
25
2
2020
entrez:
11
2
2019
Statut:
ppublish
Résumé
This study tested the hypothesis that the extent of left ventricular (LV) eccentric structural remodeling in heart failure with reduced ejection fraction (HFrEF) is directly associated with clinical event responses to cardiac resynchronization therapy (CRT). Whether the severity of LV structural remodeling influences CRT treatment effects is unknown. COMPANION (Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) trial data were analyzed retrospectively. Left ventricular internal dimensions at end diastole indexed by body surface area (LVEDDI) were measured pre-randomization by 2-dimensional echocardiography. LVEDDI values were stratified around the median value of 35 mm/m In the LVEDDI ≥35 mm/m Larger versus smaller LVEDDIs are associated with a reduction in ACM with CRT-P or CRT-D treatment, and with a more effective reduction in ACM/HFH for the combined CRT treatment groups.
Sections du résumé
OBJECTIVES
This study tested the hypothesis that the extent of left ventricular (LV) eccentric structural remodeling in heart failure with reduced ejection fraction (HFrEF) is directly associated with clinical event responses to cardiac resynchronization therapy (CRT).
BACKGROUND
Whether the severity of LV structural remodeling influences CRT treatment effects is unknown.
METHODS
COMPANION (Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure) trial data were analyzed retrospectively. Left ventricular internal dimensions at end diastole indexed by body surface area (LVEDDI) were measured pre-randomization by 2-dimensional echocardiography. LVEDDI values were stratified around the median value of 35 mm/m
RESULTS
In the LVEDDI ≥35 mm/m
CONCLUSIONS
Larger versus smaller LVEDDIs are associated with a reduction in ACM with CRT-P or CRT-D treatment, and with a more effective reduction in ACM/HFH for the combined CRT treatment groups.
Identifiants
pubmed: 30738980
pii: S2213-1779(18)30838-2
doi: 10.1016/j.jchf.2018.11.004
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
281-290Informations de copyright
Copyright © 2019 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.