No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ metabolism
Adult
Area Under Curve
Cytochrome P-450 Enzyme System
/ genetics
Dextromethorphan
/ pharmacokinetics
Dose-Response Relationship, Drug
Drug Interactions
Female
Healthy Volunteers
Humans
Hypericum
/ metabolism
Male
Phloroglucinol
/ analogs & derivatives
Plant Extracts
/ pharmacokinetics
Psychotropic Drugs
/ pharmacokinetics
Terpenes
/ pharmacokinetics
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
12
2018
accepted:
23
01
2019
pubmed:
11
2
2019
medline:
16
4
2020
entrez:
11
2
2019
Statut:
ppublish
Résumé
Hypericum perforatum L. (St. John's wort) is used to treat mild-to-moderate depression. Its potential safety risks are pharmacokinetic drug interactions via cytochrome P450 (CYP) enzymes and P-glycoprotein, presumably caused by hyperforin. In a phase I, open-label, nonrandomized, single-sequence study, the low-hyperforin Hypericum extract Ze 117 was investigated using a drug cocktail in 20 healthy volunteers. No pharmacokinetic interactions of Ze 117 were observed for CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP3A4, and P-glycoprotein. Area under the curve (AUC) and peak plasma concentration (C
Identifiants
pubmed: 30739325
doi: 10.1002/cpt.1392
pmc: PMC6766782
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Plant Extracts
0
Psychotropic Drugs
0
Terpenes
0
ZE 117
0
Dextromethorphan
7355X3ROTS
Cytochrome P-450 Enzyme System
9035-51-2
Phloroglucinol
DHD7FFG6YS
hyperforin
RM741E34FP
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
432-440Informations de copyright
© 2019 Max Zeller & Söhne AG. Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.
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