Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II-Induced Microvascular Dysfunction.
Adaptive Immunity
Angiotensin II
/ toxicity
Animals
Blood Pressure
/ physiology
Disease Models, Animal
Flow Cytometry
Hypertension
/ complications
Interleukin-6
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microcirculation
/ drug effects
Signal Transduction
T-Lymphocytes
/ immunology
Thrombosis
/ chemically induced
angiotensin II
hypertension
inflammation
interleukin-6
thrombosis
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
12
2
2019
medline:
16
11
2019
entrez:
12
2
2019
Statut:
ppublish
Résumé
Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic and inflammatory abnormalities. Although T cells and IL-6 (interleukin-6) play an important role in adaptive immune responses, little is known about their role(s) in the thromboinflammatory responses associated with Ang II. Here we show using intravital microscopy coupled with the light/dye injury model that Rag-1 deficient (Rag-1
Identifiants
pubmed: 30739537
doi: 10.1161/HYPERTENSIONAHA.118.12286
pmc: PMC6422352
mid: NIHMS1518902
doi:
Substances chimiques
Interleukin-6
0
Angiotensin II
11128-99-7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
829-838Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL134959
Pays : United States
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