Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
11 02 2019
11 02 2019
Historique:
received:
06
12
2018
accepted:
02
01
2019
entrez:
12
2
2019
pubmed:
12
2
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562-3468). We observed a genome-wide significant effect (p < 1 × 10
Identifiants
pubmed: 30741946
doi: 10.1038/s41398-019-0402-0
pii: 10.1038/s41398-019-0402-0
pmc: PMC6370792
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
77Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NICHD NIH HHS
ID : P50 HD027802
Pays : United States
Organisme : Wellcome Trust
ID : WT098017
Pays : United Kingdom
Références
Nature. 2014 Mar 27;507(7493):462-70
pubmed: 24670764
Mol Psychiatry. 2013 Apr;18(4):497-511
pubmed: 22472876
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Dev Neuropsychol. 2005;27(1):35-78
pubmed: 15737942
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
N Engl J Med. 2008 Nov 27;359(22):2337-45
pubmed: 18987363
Neuropsychologia. 2019 Jul;130:52-58
pubmed: 29803723
Sci Adv. 2016 Jun 17;2(6):e1501678
pubmed: 27386562
Behav Genet. 2001 Nov;31(6):625-35
pubmed: 11838539
Hum Mol Genet. 2007 Mar 15;16(6):667-77
pubmed: 17309879
Front Psychol. 2013 Jan 07;3:601
pubmed: 23308072
Nat Genet. 2013 Oct;45(10):1238-1243
pubmed: 24013639
J Child Psychol Psychiatry. 2013 Jun;54(6):686-94
pubmed: 23227813
Nat Biotechnol. 2017 Sep;35(9):872-878
pubmed: 28829439
Eur J Hum Genet. 2012 Feb;20(2):224-9
pubmed: 21897444
Psychol Sci. 2009 Aug;20(8):1040-8
pubmed: 19619178
Biol Psychiatry. 2009 Aug 15;66(4):368-75
pubmed: 19362708
J Learn Disabil. 2013 Nov-Dec;46(6):517-33
pubmed: 23449728
Nat Neurosci. 2014 Oct;17(10):1418-1428
pubmed: 25174004
Nucleic Acids Res. 2016 Jan 4;44(D1):D877-81
pubmed: 26657631
Bioinformatics. 2015 May 1;31(9):1466-8
pubmed: 25550326
Transl Psychiatry. 2017 Jan 3;7(1):e987
pubmed: 28045463
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8
pubmed: 16278297
J Neurodev Disord. 2011 Mar;3(1):39-49
pubmed: 21484596
Sci Stud Read. 2017 Jul 4;21(4):334-349
pubmed: 28706435
Nat Rev Neurosci. 2002 Oct;3(10):767-80
pubmed: 12360321
Am J Hum Genet. 2011 May 13;88(5):586-98
pubmed: 21565292
Mol Genet Metab. 2013 Nov;110(3):201-12
pubmed: 23916419
Mol Psychiatry. 2008 Jul;13(7):729-40
pubmed: 17684495
J Child Psychol Psychiatry. 2017 Jan;58(1):75-82
pubmed: 27501527
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Heredity (Edinb). 2005 Sep;95(3):221-7
pubmed: 16077740
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11553-8
pubmed: 12954984
Genes Brain Behav. 2013 Feb;12(1):56-69
pubmed: 23190410
Am J Hum Genet. 2004 Dec;75(6):1046-58
pubmed: 15514892
Trends Genet. 2013 Feb;29(2):66-73
pubmed: 23140989
Mol Psychiatry. 2004 Dec;9(12):1111-21
pubmed: 15249932
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
Genes Brain Behav. 2008 Nov;7(8):877-86
pubmed: 19076634
Behav Genet. 2011 Jan;41(1):50-7
pubmed: 20949370
Brain Imaging Behav. 2016 Mar;10(1):272-82
pubmed: 25953057
Genes Brain Behav. 2014 Sep;13(7):686-701
pubmed: 25065397
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Genes Brain Behav. 2014 Apr;13(4):430-8
pubmed: 24612512
Nat Methods. 2011 Sep 04;8(10):833-5
pubmed: 21892150
PLoS Genet. 2013;9(1):e1003235
pubmed: 23359524
PLoS One. 2018 Oct 31;13(10):e0206431
pubmed: 30379906
Biochem Biophys Res Commun. 2014 Sep 19;452(2):236-43
pubmed: 25078623
Eur Child Adolesc Psychiatry. 2003 Aug;12(4):198-202
pubmed: 14505070
PLoS Genet. 2009 Jun;5(6):e1000529
pubmed: 19543373
J Exp Child Psychol. 2003 Feb;84(2):97-123
pubmed: 12609495
Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15;125B(1):112-9
pubmed: 14755455
J Med Genet. 2019 Aug;56(8):557-566
pubmed: 30995994
Genes Brain Behav. 2013 Aug;12(6):645-52
pubmed: 23738518
Am J Hum Genet. 2007 Mar;80(3):531-8
pubmed: 17273975
Trends Cogn Sci. 2016 Sep;20(9):701-714
pubmed: 27422443
Ann Hum Genet. 2007 Mar;71(Pt 2):160-75
pubmed: 17038000
Am J Med Genet B Neuropsychiatr Genet. 2007 Sep 5;144B(6):709-14
pubmed: 17440942
World J Pediatr. 2009 Nov;5(4):255-64
pubmed: 19911139
Nat Rev Genet. 2011 Jun 01;12(7):465-74
pubmed: 21629274
Nature. 2016 May 11;533(7604):539-42
pubmed: 27225129
Brain Lang. 2017 Sep;172:9-15
pubmed: 27476042
Bioinformatics. 2012 Feb 1;28(3):451-2
pubmed: 22171328
PLoS Genet. 2005 Oct;1(4):e50
pubmed: 16254601
Am J Hum Genet. 2005 Apr;76(4):581-91
pubmed: 15717286
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
Behav Genet. 2011 Jan;41(1):90-104
pubmed: 21165691
J Child Psychol Psychiatry. 2004 Jan;45(1):2-40
pubmed: 14959801
Mol Psychiatry. 2006 Dec;11(12):1085-91, 1061
pubmed: 17033633
J Neurodev Disord. 2016 May 15;8:17
pubmed: 27186239
Bioinformatics. 2007 May 15;23(10):1294-6
pubmed: 17384015
Genes Brain Behav. 2016 Jul;15(6):531-41
pubmed: 27198479
Lancet. 2003 Mar 8;361(9360):865-72
pubmed: 12642066
Annu Rev Clin Psychol. 2015;11:283-307
pubmed: 25594880
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
PLoS One. 2010 Oct 28;5(10):e13712
pubmed: 21060895
Eur J Hum Genet. 2014 May;22(5):675-80
pubmed: 24022301
Psychiatr Genet. 2015 Feb;25(1):9-20
pubmed: 25426763
BMC Neurol. 2013 Dec 13;13:198
pubmed: 24330722
Cognition. 2006 Sep;101(2):385-413
pubmed: 16844106
Psychiatr Genet. 2012 Feb;22(1):25-30
pubmed: 21881542
Dyslexia. 2013 Nov;19(4):214-40
pubmed: 24133036
Behav Genet. 2017 Sep;47(5):469-479
pubmed: 28711986
PLoS Genet. 2009 Mar;5(3):e1000436
pubmed: 19325871
Nature. 2015 Apr 9;520(7546):224-9
pubmed: 25607358
PLoS Genet. 2013;9(9):e1003751
pubmed: 24068947
Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):503-511
pubmed: 19591125
Mol Psychiatry. 2011 Jan;16(1):97-107
pubmed: 19786962
Nat Methods. 2013 Jan;10(1):5-6
pubmed: 23269371
Am J Med Genet B Neuropsychiatr Genet. 2008 Apr 5;147(3):294-300
pubmed: 17886254
Dev Neuropsychol. 2001;20(2):483-507
pubmed: 11892949
PLoS One. 2014 Jul 29;9(7):e103537
pubmed: 25072465
Schizophr Res. 2018 Mar;193:11-22
pubmed: 28688740
Biol Psychiatry. 2007 Oct 1;62(7):811-7
pubmed: 17597587
Annu Rev Psychol. 2009;60:283-306
pubmed: 18652545
Am J Med Genet. 2000 Jun 12;96(3):293-301
pubmed: 10898903
Am J Hum Genet. 2006 Jan;78(1):52-62
pubmed: 16385449
Twin Res Hum Genet. 2011 Jun;14(3):228-32
pubmed: 21623652
Annu Rev Psychol. 2012;63:427-52
pubmed: 21838545
Mol Autism. 2017 May 22;8:21
pubmed: 28540026
Genes Brain Behav. 2013 Nov;12(8):792-801
pubmed: 24024963
Cortex. 2010 Nov-Dec;46(10):1345-61
pubmed: 20828676
Elife. 2015 Aug 12;4:
pubmed: 26267216