Lung CT Densitometry in Idiopathic Pulmonary Fibrosis for the Prediction of Natural Course, Severity, and Mortality.
Aged
Analysis of Variance
Biopsy, Needle
Cause of Death
Cohort Studies
Disease Progression
Female
Humans
Idiopathic Pulmonary Fibrosis
/ diagnostic imaging
Immunohistochemistry
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Severity of Illness Index
Survival Analysis
Tomography, X-Ray Computed
/ methods
Total Lung Capacity
/ physiology
Vital Capacity
CT densitometry
HRCT index
disease prediction parameters
idiopathic pulmonary fibrosis
Journal
Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
08
06
2018
revised:
21
11
2018
accepted:
02
01
2019
pubmed:
12
2
2019
medline:
20
2
2020
entrez:
12
2
2019
Statut:
ppublish
Résumé
In this study, we retrospectively assessed the relationships among physiologic measurements, survival, and quantitative high-resolution CT (HRCT) scanning indexes in patients with idiopathic pulmonary fibrosis (IPF). Seventy patients (48 male; mean [SD] age, 66.4 [9.0] years) with IPF were enrolled in the study. After segmentation of the lungs in thin-section CT scanning with the patient in the supine position at full inspiration, we assessed following parameters: mean lung attenuation (MLA), skewness, kurtosis, peak attenuation, total lung area, inflexion point with slope, and area right of the inflexion point (AROIP). Additionally, FVC, FEV The strongest correlation was observed between MLA and FEV These data indicate that HRCT scanning indexes are correlated to physiologic measurements. The newly defined parameter, AROIP, is of additive value for prediction of outcome. ClinicalTrials.gov; No.: NCT02951416; URL: www.clinicaltrials.gov.
Sections du résumé
BACKGROUND
In this study, we retrospectively assessed the relationships among physiologic measurements, survival, and quantitative high-resolution CT (HRCT) scanning indexes in patients with idiopathic pulmonary fibrosis (IPF).
METHODS
Seventy patients (48 male; mean [SD] age, 66.4 [9.0] years) with IPF were enrolled in the study. After segmentation of the lungs in thin-section CT scanning with the patient in the supine position at full inspiration, we assessed following parameters: mean lung attenuation (MLA), skewness, kurtosis, peak attenuation, total lung area, inflexion point with slope, and area right of the inflexion point (AROIP). Additionally, FVC, FEV
RESULTS
The strongest correlation was observed between MLA and FEV
CONCLUSIONS
These data indicate that HRCT scanning indexes are correlated to physiologic measurements. The newly defined parameter, AROIP, is of additive value for prediction of outcome.
TRIAL REGISTRY
ClinicalTrials.gov; No.: NCT02951416; URL: www.clinicaltrials.gov.
Identifiants
pubmed: 30742809
pii: S0012-3692(19)30128-X
doi: 10.1016/j.chest.2019.01.019
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02951416']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
972-981Informations de copyright
Copyright © 2019 American College of Chest Physicians. All rights reserved.