Cochlear ablation in neonatal rats disrupts inhibitory transmission in the medial nucleus of the trapezoid body.
Ablation Techniques
Animals
Animals, Newborn
Cochlea
/ physiopathology
Evoked Potentials, Auditory, Brain Stem
/ physiology
GABA-A Receptor Agonists
/ pharmacology
Inhibitory Postsynaptic Potentials
/ physiology
Male
Neural Inhibition
/ drug effects
Rats
Receptors, GABA-A
/ physiology
Receptors, Glycine
/ agonists
Synaptic Transmission
Trapezoid Body
/ physiology
Vesicular Inhibitory Amino Acid Transport Proteins
/ metabolism
Auditory
Cochlear ablation
GABA
Glycine
MNTB
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
23 04 2019
23 04 2019
Historique:
received:
09
06
2018
revised:
11
01
2019
accepted:
31
01
2019
pubmed:
12
2
2019
medline:
18
12
2019
entrez:
12
2
2019
Statut:
ppublish
Résumé
Inhibitory circuits in the auditory brainstem undergo multiple postnatal changes that are both activity-dependent and activity-independent. We tested to see if the shift from GABA- to glycinergic transmission, which occurs in the rat medial nucleus of the trapezoid body (MNTB) around the onset of hearing, depends on sound-evoked neuronal activity. We prevented the activity by bilateral cochlear ablations in early postnatal rats and studied ionotropic GABA and glycine receptors in MNTB neurons after hearing onset. The removal of the cochlea decreased responses of GABA
Identifiants
pubmed: 30742935
pii: S0304-3940(19)30076-X
doi: 10.1016/j.neulet.2019.01.058
pii:
doi:
Substances chimiques
GABA-A Receptor Agonists
0
Receptors, GABA-A
0
Receptors, Glycine
0
Vesicular Inhibitory Amino Acid Transport Proteins
0
vesicular GABA transporter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
145-150Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.