Both Val158Met Polymorphism of Catechol-O-Methyltransferase Gene and Menstrual Cycle Affect Prepulse Inhibition but Not Attentional Modulation of Prepulse Inhibition in Younger-Adult Females.
Val153Met polymorphism
attentional modulation
menstrual cycle
perceived spatial separation
precedence effect
prepulse inhibition
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
04
09
2018
revised:
30
01
2019
accepted:
01
02
2019
pubmed:
12
2
2019
medline:
25
12
2019
entrez:
12
2
2019
Statut:
ppublish
Résumé
Prepulse inhibition (PPI) can be modulated by both the Val158Met (rs4680) polymorphism of the Catechol-O-Methyltransferase (COMT) gene and the menstrual-cycle-related hormone fluctuations, each of which affects the subcortical/cortical dopamine metabolism. PPI can also be modulated by attention. The attentional modulation of PPI (AMPPI) is sensitive to psychoses. Whether the Val158Met polymorphism affects the AMPPI in female adults at different menstrual-cycle phases is unknown. This study examined whether AMPPI and/or PPI are affected by the Val158Met polymorphism in 177 younger-adult females whose menstrual cycles were mutually different across the menstruation, proliferative, or secretory phases. The AMPPI was evaluated by comparing PPI under the condition of the auditory precedence-effect-induced perceptual spatial separation between the prepulse stimulus and a masking noise (PPI
Identifiants
pubmed: 30742958
pii: S0306-4522(19)30094-6
doi: 10.1016/j.neuroscience.2019.02.001
pii:
doi:
Substances chimiques
Methionine
AE28F7PNPL
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Valine
HG18B9YRS7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
396-406Informations de copyright
Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.