Antibodies Against the C-Terminus of ApoA-1 Are Inversely Associated with Cholesterol Efflux Capacity and HDL Metabolism in Subjects with and without Type 2 Diabetes Mellitus.
Antibodies, Monoclonal
/ pharmacology
Apolipoprotein A-I
/ antagonists & inhibitors
Biological Transport
Biomarkers
Case-Control Studies
Cholesterol
/ metabolism
Cholesterol, HDL
/ metabolism
Diabetes Mellitus, Type 2
/ metabolism
Female
Humans
Lipid Metabolism
/ drug effects
Male
Protein Interaction Domains and Motifs
/ drug effects
Type 2 diabetes mellitus
anti-apoA-1 autoantibodies
cholesterol efflux capacity
cholesterol esterification
cholesteryl ester transfer
high-density lipoproteins
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
09 Feb 2019
09 Feb 2019
Historique:
received:
22
01
2019
revised:
06
02
2019
accepted:
06
02
2019
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
30
5
2019
Statut:
epublish
Résumé
We determined relationships of cholesterol efflux capacity (CEC), plasma cholesterol esterification (EST) and cholesteryl ester transfer (CET) with anti-c-terminus apoA-1 (Ac-terAA1) and anti-apolipoprotein (apo)-1 (AAA1) autoantibodies in subjects with and without Type 2 diabetes mellitus (T2D). In 75 T2D subjects and 75 nondiabetic subjects, Ac-terAA1 and AAA1 plasma levels were measured by enzyme-linked immunosorbent assay. CEC was measured as [³H]-cholesterol efflux from human cultured fibroblasts to diluted individual subject plasma. Plasma EST and CET were assayed by isotope methods. Ac-terAA1 and AAA1 levels and were similar between T2D and control subjects. Univariate regression analysis ( CEC, plasma EST and CET are inversely associated with Ac-terAA1 autoantibodies, conceivably attributable to an inverse relationship of these autoantibodies with apolipoprotein B-containing lipoproteins.
Sections du résumé
BACKGROUND
BACKGROUND
We determined relationships of cholesterol efflux capacity (CEC), plasma cholesterol esterification (EST) and cholesteryl ester transfer (CET) with anti-c-terminus apoA-1 (Ac-terAA1) and anti-apolipoprotein (apo)-1 (AAA1) autoantibodies in subjects with and without Type 2 diabetes mellitus (T2D).
METHODS
METHODS
In 75 T2D subjects and 75 nondiabetic subjects, Ac-terAA1 and AAA1 plasma levels were measured by enzyme-linked immunosorbent assay. CEC was measured as [³H]-cholesterol efflux from human cultured fibroblasts to diluted individual subject plasma. Plasma EST and CET were assayed by isotope methods.
RESULTS
RESULTS
Ac-terAA1 and AAA1 levels and were similar between T2D and control subjects. Univariate regression analysis (
CONCLUSIONS
CONCLUSIONS
CEC, plasma EST and CET are inversely associated with Ac-terAA1 autoantibodies, conceivably attributable to an inverse relationship of these autoantibodies with apolipoprotein B-containing lipoproteins.
Identifiants
pubmed: 30744100
pii: ijms20030732
doi: 10.3390/ijms20030732
pmc: PMC6387386
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Apolipoprotein A-I
0
Biomarkers
0
Cholesterol, HDL
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest
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