Ablation of both Cx40 and Panx1 results in similar cardiovascular phenotypes exhibited in Cx40 knockout mice.
Pannexin 1
connexin
gap junctions
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
28 02 2019
28 02 2019
Historique:
received:
06
11
2018
revised:
10
01
2019
accepted:
05
02
2019
pubmed:
13
2
2019
medline:
29
1
2020
entrez:
13
2
2019
Statut:
epublish
Résumé
Connexins (Cxs) and pannexins (Panxs) are highly regulated large-pore channel-forming proteins that participate in cellular communication via small molecular exchange with the extracellular microenvironment, or in the case of connexins, directly between cells. Given the putative functional overlap between single membrane-spanning connexin hemichannels and Panx channels, and cardiovascular system prevalence, we generated the first Cx40
Identifiants
pubmed: 30745457
pii: BSR20182350
doi: 10.1042/BSR20182350
pmc: PMC6393227
pii:
doi:
Substances chimiques
Connexins
0
Nerve Tissue Proteins
0
Panx1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL120840
Pays : United States
Organisme : CIHR
ID : 130530
Pays : Canada
Informations de copyright
© 2019 The Author(s).
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