Renal toxicities associated with pembrolizumab.
acute interstitial nephritis
acute kidney injury
acute tubular injury
minimal change nephropathy
pembrolizumab
Journal
Clinical kidney journal
ISSN: 2048-8505
Titre abrégé: Clin Kidney J
Pays: England
ID NLM: 101579321
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
20
06
2018
accepted:
05
09
2018
entrez:
13
2
2019
pubmed:
13
2
2019
medline:
13
2
2019
Statut:
ppublish
Résumé
Expanded clinical experience with patients treated by pembrolizumab has accumulated. However, renal toxicities associated with this anti-programmed cell death 1 agent are poorly described because kidney histology is rarely sought. As a nephrology referral centre, we aimed to describe the clinic-biological and histopathological characteristics of pembrolizumab-related nephropathy and its response to treatment. We conducted a monocentric large case series study, including all pembrolizumab-treated cancer patients presenting a renal toxicity addressed to our centre from 2015 to 2017. A total of 12 patients (7 men) out of 676 pembrolizumab-treated patients (incidence 1.77%) were included (median age 69.75 years). Patients were referred for acute kidney injury ( In our series, ATI, AIN and MCD are the most frequent forms of kidney involvement under pembrolizumab therapy. Kidney dysfunction is usually isolated but can be severe. Use of corticosteroids in case of AIN improves the glomerular filtration rate.
Identifiants
pubmed: 30746132
doi: 10.1093/ckj/sfy100
pii: sfy100
pmc: PMC6366307
doi:
Types de publication
Journal Article
Langues
eng
Pagination
81-88Références
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