Pyramidal neuron growth and increased hippocampal volume during labor and birth in autism.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
01 2019
Historique:
received: 08 08 2018
accepted: 10 12 2018
entrez: 13 2 2019
pubmed: 13 2 2019
medline: 9 4 2020
Statut: epublish

Résumé

We report that the apical dendrites of CA3 hippocampal pyramidal neurons are increased during labor and birth in the valproate model of autism but not in control animals. Using the iDISCO clearing method, we show that hippocampal, especially CA3 region, and neocortical volumes are increased and that the cerebral volume distribution shifts from normal to lognormal in valproate-treated animals. Maternal administration during labor and birth of the NKCC1 chloride transporter antagonist bumetanide, which reduces [Cl

Identifiants

pubmed: 30746473
doi: 10.1126/sciadv.aav0394
pii: aav0394
pmc: PMC6357736
doi:

Substances chimiques

GABA Agents 0
Sodium Potassium Chloride Symporter Inhibitors 0
Bumetanide 0Y2S3XUQ5H
Valproic Acid 614OI1Z5WI

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaav0394

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Auteurs

R Cloarec (R)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

B Riffault (B)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

A Dufour (A)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

H Rabiei (H)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

L-A Gouty-Colomer (LA)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

C Dumon (C)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

D Guimond (D)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

P Bonifazi (P)

Biocruces Health Research Institute, Barakaldo, Spain & IKERBASQUE: The Basque Foundation for Science, Bilbao, Spain.

S Eftekhari (S)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

N Lozovaya (N)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

D C Ferrari (DC)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

Y Ben-Ari (Y)

Neurochlore, Ben-Ari Institute of Neuroarcheology (IBEN), Zone Luminy Biotech Entreprises, 13288 Cedex 09 , Marseille, France.

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