Monitoring the effectiveness of hypothermia in perinatal asphyxia infants by urinary S100B levels.

Asphyxia / pathology Biomarkers / urine Brain / physiology Case-Control Studies Electroencephalography Female Humans Hypothermia, Induced Hypoxia-Ischemia, Brain / pathology Immunoassay Infant, Newborn Male Retrospective Studies S100 Calcium Binding Protein beta Subunit / urine Severity of Illness Index

S100B asphyxia hypothermia neonate

Journal

Clinical chemistry and laboratory medicine

ISSN: 1437-4331

Titre abrégé: Clin Chem Lab Med

Pays: Germany

ID NLM: 9806306

Informations de publication

Date de publication:
26 06 2019

Historique:

received: 09 10 2018

accepted: 18 01 2019

pubmed: 13 2 2019

medline: 26 2 2020

entrez: 13 2 2019

Statut: ppublish

Résumé

Background Perinatal asphyxia is a major cause of mortality and morbidity in neonates: The aim of the present study was to investigate, by means of longitudinal assessment of urinary S100B, the effectiveness of hypothermia, in infants complicated by perinatal asphyxia and hypoxic-ischemic encephalopathy. Methods We performed a retrospective case-control study in 108 asphyxiated infants, admitted to nine tertiary departments for neonatal intensive care from January 2004 to July 2017, of whom 54 underwent hypothermia treatment and 54 did not. The concentrations of S100B protein in urine were measured using an immunoluminometric assay at first urination and 4, 8, 12, 16, 20, 24, 48, 72, 96, 108 and 120 h after birth. The results were correlated with the achievement of S100B levels within normal ranges at 72 h from hypothermia treatment. Routine laboratory parameters, longitudinal cerebral function monitoring, cerebral ultrasound and neurologic patterns were assessed according to standard protocols. Results Higher S100B concentrations were found in hypothermia-treated infants in both moderate (up to 12 h) and severe (up to 24 h) hypoxic-ischemic encephalopathy. S100B levels returned to normal ranges starting from 20 h of hypothermia treatment in moderate and from 36 h in severe hypoxic-ischemic encephalopathy. Conclusions The present results offer additional support to the usefulness of longitudinal neuro-biomarkers monitoring in asphyxiated infants treated by hypothermia. The pattern of S100B concentrations during hypothermia supports the need for further investigations aimed at reconsidering the time-window for patient recruitment and treatment, and the optimal duration of the cooling and rewarming phases of the hypothermia procedure.

Identifiants

DOI: 10.1515/cclm-2018-1094 PMID: 30753152

pubmed: 30753152

doi: 10.1515/cclm-2018-1094

pii: cclm-2018-1094

doi:

Substances chimiques

Biomarkers 0

S100 Calcium Binding Protein beta Subunit 0

S100B protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

1017-1025

Références

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