Macronutrient content of pooled donor human milk before and after Holder pasteurization.
Donor human milk
Macronutrients
Pasteurization
Tailored fortification
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
12 02 2019
12 02 2019
Historique:
received:
31
08
2018
accepted:
05
02
2019
entrez:
14
2
2019
pubmed:
14
2
2019
medline:
5
3
2020
Statut:
epublish
Résumé
Donor human milk (DHM) is the best alternative for preterm infants when their own mother's milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influence the macronutrient content. The aim of this study was to investigate the effect of Holder pasteurization (HoP) on DHM macronutrient content. Protein, lactose, lipids (g/100 ml) and energy (kcal/100 ml) of DHM pools were analysed before and after HoP (62.5 °C for 30 min) using mid-infrared spectroscopy (HM analyser Miris AB®). The mean macronutrient content before and after HoP was compared by paired t-test. The percentage decreases (Delta%) were calculated. The change in macronutrient content of 460 pools was determined. Protein, lipids and lactose decreased significantly after HoP (0.88 ± 0.20 vs 0.86 ± 0.20 and 2.91 ± 0.89 vs 2.75 ± 0.84 and 7.19 ± 0.41 vs 7.11 ± 0.48 respectively). The Delta% values were - 2.51 ± 13.12, - 4.79 ± 9.47 and - 0.92 ± 5.92 for protein, lipids and lactose, respectively (p ≤ 0.001). This study confirms that the macronutrient content of DHM, especially in terms of lipids and protein, is reduced after HoP. Therefore, in order to perform a tailored fortification of DHM, the clinicians need to be aware of the somewhat diminished nutrient content of DHM.
Sections du résumé
BACKGROUND
Donor human milk (DHM) is the best alternative for preterm infants when their own mother's milk is unavailable. DHM should be pasteurized to guarantee microbiological safety; however, this process can influence the macronutrient content. The aim of this study was to investigate the effect of Holder pasteurization (HoP) on DHM macronutrient content.
METHODS
Protein, lactose, lipids (g/100 ml) and energy (kcal/100 ml) of DHM pools were analysed before and after HoP (62.5 °C for 30 min) using mid-infrared spectroscopy (HM analyser Miris AB®). The mean macronutrient content before and after HoP was compared by paired t-test. The percentage decreases (Delta%) were calculated.
RESULTS
The change in macronutrient content of 460 pools was determined. Protein, lipids and lactose decreased significantly after HoP (0.88 ± 0.20 vs 0.86 ± 0.20 and 2.91 ± 0.89 vs 2.75 ± 0.84 and 7.19 ± 0.41 vs 7.11 ± 0.48 respectively). The Delta% values were - 2.51 ± 13.12, - 4.79 ± 9.47 and - 0.92 ± 5.92 for protein, lipids and lactose, respectively (p ≤ 0.001).
CONCLUSION
This study confirms that the macronutrient content of DHM, especially in terms of lipids and protein, is reduced after HoP. Therefore, in order to perform a tailored fortification of DHM, the clinicians need to be aware of the somewhat diminished nutrient content of DHM.
Identifiants
pubmed: 30755170
doi: 10.1186/s12887-019-1427-5
pii: 10.1186/s12887-019-1427-5
pmc: PMC6373112
doi:
Substances chimiques
Lipids
0
Milk Proteins
0
Lactose
J2B2A4N98G
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
58Références
J Hum Lact. 2010 Nov;26(4):376-83
pubmed: 20871090
Ital J Pediatr. 2016 Apr 07;42:36
pubmed: 27056486
Am J Clin Nutr. 2017 Feb;105(2):379-390
pubmed: 28052887
J Transl Med. 2016 Jul 01;14(1):195
pubmed: 27370649
J Pediatr. 2013 Oct;163(4):1001-7
pubmed: 23769498
Curr Opin Clin Nutr Metab Care. 2015 May;18(3):269-75
pubmed: 25769062
PLoS One. 2016 Feb 10;11(2):e0148941
pubmed: 26863130
J Pediatr Gastroenterol Nutr. 2016 Jun;62(6):901-6
pubmed: 26794491
Nutrients. 2016 Aug 02;8(8):
pubmed: 27490567
J Matern Fetal Neonatal Med. 2019 Sep;32(18):3016-3019
pubmed: 29587541
J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):85-91
pubmed: 19881390
Pediatr Med Chir. 2017 Jun 28;39(2):158
pubmed: 28673079
Ann Nutr Metab. 2016;69 Suppl 2:8-15
pubmed: 28103607
J Matern Fetal Neonatal Med. 2010 Sep;23 Suppl 2:1-20
pubmed: 20840052
Early Hum Dev. 2011 Aug;87(8):577-80
pubmed: 21592688
Nutrients. 2018 Feb 20;10(2):
pubmed: 29461479
J Perinatol. 2016 Mar;36(3):216-20
pubmed: 26562370
Semin Perinatol. 2017 Feb;41(1):36-40
pubmed: 27836421
Pediatrics. 2012 Mar;129(3):e827-41
pubmed: 22371471
Breastfeed Med. 2016 Mar;11(2):70-4
pubmed: 26789484
Pediatrics. 2017 Jan;139(1):
pubmed: 27994111
World Rev Nutr Diet. 2014;110:201-14
pubmed: 24751631
J Pediatr Gastroenterol Nutr. 2017 Mar;64(3):353-361
pubmed: 27755345
Cochrane Database Syst Rev. 2007 Oct 17;(4):CD002971
pubmed: 17943776
Front Biosci (Elite Ed). 2011 Jun 01;3:818-29
pubmed: 21622093
J Pediatr Gastroenterol Nutr. 2013 Sep;57(3):377-82
pubmed: 23752081