Annexin A1-derived peptide Ac

Animals Annexin A1 / metabolism Anticonvulsants / therapeutic use Blood-Brain Barrier / drug effects Cytokines / metabolism Diazepam / therapeutic use Disease Models, Animal Gliosis / etiology Hippocampus / drug effects MAP Kinase Signaling System / drug effects Male Muscarinic Agonists / toxicity Nerve Degeneration / drug therapy Nerve Tissue Proteins / metabolism Neuroglia / pathology Neurons / drug effects Neuroprotective Agents / therapeutic use Peptides / therapeutic use Pilocarpine / toxicity Rats Rats, Wistar Receptors, Lipoxin / metabolism Status Epilepticus / chemically induced
Cytokines ERK Fpr2 Glia Hippocampus Neuroinflammation

Journal

Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974

Informations de publication

Date de publication:
12 Feb 2019
Historique:
received: 06 11 2018
accepted: 24 01 2019
entrez: 14 2 2019
pubmed: 14 2 2019
medline: 29 5 2019
Statut: epublish

Résumé

The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac Male Wistar rats were divided into Naive, Sham, SE and SE+Ac Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac The data suggest a neuroprotective effect of Ac

Sections du résumé

BACKGROUND BACKGROUND
The inflammatory process has been described as a crucial mechanism in the pathophysiology of temporal lobe epilepsy. The anti-inflammatory protein annexin A1 (ANXA1) represents an interesting target in the regulation of neuroinflammation through the inhibition of leukocyte transmigration and the release of proinflammatory mediators. In this study, the role of the ANXA1-derived peptide Ac
METHODS METHODS
Male Wistar rats were divided into Naive, Sham, SE and SE+Ac
RESULTS RESULTS
Pilocarpine induced generalised SE in all animals, causing neuronal damage, and systemic treatment with Ac
CONCLUSIONS CONCLUSIONS
The data suggest a neuroprotective effect of Ac

Identifiants

DOI: 10.1186/s12974-019-1414-7 PMID: 30755225 PMC: PMC6371492
pubmed: 30755225
doi: 10.1186/s12974-019-1414-7
pii: 10.1186/s12974-019-1414-7
pmc: PMC6371492
doi:

Substances chimiques

Annexin A1 0
Anticonvulsants 0
Cytokines 0
Muscarinic Agonists 0
Nerve Tissue Proteins 0
Neuroprotective Agents 0
Peptides 0
Receptors, Lipoxin 0
annexin A1 peptide (2-26) 0
lipoxin A(4) receptor, rat 0
Pilocarpine 01MI4Q9DI3
Diazepam Q3JTX2Q7TU

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

32

Subventions

Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2017/26872-5
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : 2016/02012-4
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 308144/2014-7
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : 001

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Auteurs

Alexandre D Gimenes (AD)

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.

Bruna F D Andrade (BFD)

Department of Molecular Biology, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, SP, 15090-000, Brazil.

José Victor P Pinotti (JVP)

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.

Sonia M Oliani (SM)

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil.
From the Post-Graduation in Biosciences, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (IBILCE/UNESP), São José do Rio Preto, SP, 15054-000, Brazil.

Orfa Y Galvis-Alonso (OY)

Department of Molecular Biology, São José do Rio Preto School of Medicine (FAMERP), São José do Rio Preto, SP, 15090-000, Brazil.

Cristiane D Gil (CD)

Department of Morphology and Genetics, Federal University of São Paulo (UNIFESP), São Paulo, SP, 04023-900, Brazil. cristiane.gil@unifesp.br.
From the Post-Graduation in Biosciences, Instituto de Biociências, Letras e Ciências Exatas, São Paulo State University (IBILCE/UNESP), São José do Rio Preto, SP, 15054-000, Brazil. cristiane.gil@unifesp.br.
ORCID: 0000-0001-6979-4126

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Annexin A1-derived peptide Ac
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Annexines › Annexine A1 › Annexin A1-derived peptide Ac
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Anticonvulsivants › Annexin A1-derived peptide Ac
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Annexin A1-derived peptide Ac
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Annexin A1-derived peptide Ac
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Benzodiazépinones › Diazépam › Annexin A1-derived peptide Ac
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Annexin A1-derived peptide Ac
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Gliose › Annexin A1-derived peptide Ac
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Annexin A1-derived peptide Ac
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Annexin A1-derived peptide Ac
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Agonistes cholinergiques › Agonistes muscariniques › Annexin A1-derived peptide Ac
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Dégénérescence nerveuse › Annexin A1-derived peptide Ac
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Annexin A1-derived peptide Ac
questionsmedicales.fr › Cellules › Névroglie › Annexin A1-derived peptide Ac
questionsmedicales.fr › Cellules › Neurones › Annexin A1-derived peptide Ac
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Annexin A1-derived peptide Ac
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Annexin A1-derived peptide Ac
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Pilocarpine › Annexin A1-derived peptide Ac
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Annexin A1-derived peptide Ac
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Annexin A1-derived peptide Ac
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux éicosanoïdes › Récepteurs de la lipoxine › Annexin A1-derived peptide Ac
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › État de mal épileptique › Annexin A1-derived peptide Ac